Accumulated studies have suggested that mitogen-activated protein kinase (MAPK) play a pivotal role in the development of cerebral hypoxic preconditioning (HPC). By using our "auto-hypoxia"-induced HPC mouse model, we have reported increased phosphorylation level of p38 MAPK, and decreased phosphorylation and protein expression levels of extracellular signal regulated kinases 1/2 (ERK1/2) in th...

This study aims to assess the effect of sodium chloride attack on mechanical and durability properties high-performance concrete (HPC) based fibers natural pozzolans. The resistance specimens against chemical is determined by unit weight, compressive strength, splitting-tensile ion permeability, apparent gas visual inspection after 28, 90, 180, 365 days testing. A total three types are assessed...

The host tissue microenvironment influences malignant cell proliferation and metastasis, but little is known about how tumor-induced changes in the microenvironment affect benign cellular ecosystems. Applying dynamic in vivo imaging to a mouse model, we show that leukemic cell growth disrupts normal hematopoietic progenitor cell (HPC) bone marrow niches and creates abnormal microenvironments th...

The contribution of specific cell types to the production of cytokines that regulate hematopoiesis is still not well defined. We have previously identified T cell-dependent regulation of hematopoietic progenitor cell (HPC) numbers and cycling. In this report, we demonstrated that HPC activity is decreased in mice with STAT3-deficient T cells, a phenotype that is not because of decreased express...

Traditionally high-performance computing (HPC) systems have been optimized to support mostly monolithic workloads. The workload of many important scientific applications however, is comprised of spatially and temporally heterogeneous tasks that are often dynamically inter-related. These workloads can benefit from being executed at scale on HPC resources but a tension exists between their resour...

Key computational kernels must run near their peak efficiency for most high performance computing (HPC) applications. Getting this level of efficiency has always required extensive tuning of the kernel on a particular platform of interest. The success or failure of an optimization is usually measured by invoking a timer. Understanding how to build reliable and context-sensitive timers is one of...

In this article we describe the application of HPC standard benchmark tests to Amazon’s EC2 cloud computing system, in order to explore the utility of EC2 for modest HPC style applications. Based on these benchmarks we find that the EC2 cloud system is emerging as a credible solution for supporting responsive on-demand, small sized, HPC applications. We illustrate this point with a demonstratio...

T he idea of green high-performance computing (HPC) has been gaining traction over the past fi ve years. In November 2008, the Green 500 list (www.green500.org) was introduced to “raise awareness about power consumption, promote alternative total cost of ownership performance metrics, and ensure that supercomputers only simulate climate change and not create it.” The Green 500 lists the world’s...

Heterotrophic plate count (HPC) constitutes a common indicator for monitoring of microbiological water quality in distribution systems (DS). This paper aims to identify factors explaining the spatiotemporal distribution of heterotrophic bacteria and model their occurrence in the distribution system. The case under study is the DS of Quebec City, Canada. The study is based on a robust database r...