CONTEXT  Nauclea latifolia Smith (Rubiaceae) is a small tree found in tropical areas in Africa. It is used in traditional medicine to treat malaria, epilepsy, anxiety, pain, fever, etc. OBJECTIVE  The aim of this study was to investigate the effects of Nauclea latifolia roots decoction on the peripheral and central nervous systems and its possible mechanisms of action. MATERIALS AND METHODS...

the selected parts of four medicinal plants, achillea millefolium, hibiscus rosasinensis, linum usitatissimum and pluchea lanceolata were extracted in absolute methanol to determine their analgesic activity. analgesic activity was assessed on intact mice by tail flick latency via the tail immersion method. the analgesic activities of these plant extracts were compared with acetylsalicylic acid ...

In this study, the analgesic, antipyretic and anti-inflammatory effects of the methanolic extract obtained from the leaves of Thunbergia coccinea Wall were investigated. Analgesic effect of MTC was evaluated by acetic acid –induced writhing, hot plate and tail flick method. Antipyretic activity of MTC was evaluated by yeast –induced hyperpyrexia in rats. The antiinflammatory activity was studie...

Treatment of mouse tail skins with hexachlorophene (1.25% w/v) in abso­ lute methanol or 70% isopropanol suppressed Schistosoma mansoni infections by more than 95% even when the application was performed up to three days prior to exposure to cercarial suspensions by tail immersion. Treatment with concen­ trations of 0.313% or higher one day prior to exposure provided at least 98% protection whe...

Morphine induces antinociception by activating mu opioid receptors (muORs) in spinal and supraspinal regions of the CNS. (Beta)arrestin-2 (beta)arr2), a G-protein-coupled receptor-regulating protein, regulates the muOR in vivo. We have shown previously that mice lacking (beta)arr2 experience enhanced morphine-induced analgesia and do not become tolerant to morphine as determined in the hot-plat...

1. The pharmacological modulation of opioid actions by drugs acting on heterologous mechanisms could be useful to overcome some of the main problems associated with the use of opiate agonists. Based on previous findings on the interactions between yohimbine and opioid drugs, we have further studied the effects of yohimbine on the antinociceptive and positive-negative reinforcing effects of morp...

s | 35 Conclusions: Our findings provide valuable information for personalized pain treatment after LAC, in which the C allele of the rs2076222 SNP is associated with lower opioid sensitivity and/ or higher pain sensitivity and requires more opioid analgesic after LAC. PT642 The effects of caffeine on acupuncture analgesia Jeong Won Hwang, Shoji Shinohara, Tadashi Watsuji, Katsuki Watanabe Abst...

submitted after deadline Evaluation of anaesthetic activity of some aminoalkanol derivatives Tadeusz Librowski1, Anna M. Waszkielewicz2, Barbara Filipek1, Henryk Marona2 !! " #$% & ' !! " # % Derivatives of aminoalkanols such as KM113 and KM314 are considered anticonvulsant drug candidates, and they exhibit sodium channel blocking effect. Therefore, the aim of the study was to determine possibl...

The ethanol and water extracts of Sansevieria trifasciata leaves showed dose-dependent and significant (P < 0.05) increase in pain threshold in tail-immersion test. Moreover, both the extracts (100 - 200 mg/kg) exhibited a dose-dependent inhibition of writhing and also showed a significant (P < 0.001) inhibition of both phases of the formalin pain test. The ethanol extract (200 mg/kg) significa...

The effects of spironolactone, a non-selective aldosterone antagonist, were examined on thermally-induced pain using the hot-plate and tail-flick tests, on chemogenic pain induced by intraplantar capsaicin, on electrically-induced pain, on visceral nociception induced by intraperitoneal acetic acid injection and on haloperidol-induced catalepsy in mice. Spironolactone significantly shortened re...