Oral solid dosage forms are the most patient-accepted and therefore industrially relevant pharmaceutical applications, representing 80% of the market share. In that context, polymer processing techniques, such as hot melt extrusion (HME) or injection molding (IM), are increasingly used to process primary material into the final dosage forms due to several benefits (e.g., enhanced solubility or ...

The aim of this study was to investigate the influence of pH, buffer species and ionic strength on the release mechanism of Glipizide (G) from matrix tablets containing chitosan and xanthan gum prepared by a hot-melt extrusion process. The release mechanisms were controlled by the solubility and ionic properties of the polymers. All directly compressed (DC) tablets prepared in this study also e...

The capsule drug ring (CDR) is a reservoir and delivery agent, which is designed to be placed within the capsular bag during cataract surgery. Prototypes were manufactured by hot melt extrusion of Bionate II®, a polycarbonate urethane. The devices have been optimized using Avastin® as the drug of interest. In vitro biocompatibility was assessed with human lens epithelial cell (B-3), mouse macro...

In this report a concise review is given of the literature on slip phenomena at the wall of extrusion devices and the role of slip-laws in modeling of extrusion instabilities. In section 2 the main three instabilities are discussed: spurt, in which big pressure oscillations occur and the extrudate leaves the die in an oscillating way, sharkskin, which leads to more or less regular surface defec...

Stereo topography of an area near Tyre impact crater, Europa, reveals chaos regions characterised by marginal cliffs and domical topography, rising to 100–200 m above the background plains. The regions contain blocks which have both rotated and tilted. We tested two models of chaos formation: a hybrid diapir model, in which chaos topography is caused by thermal or compositional buoyancy, and bl...

In the present study, AZ41 and AZ51 alloys were fabricated using disintegrated melt deposition technique followed by hot extrusion. AZ41/Yttria and AZ51/Yttria composites were prepared using 0.6 wt% yttria nano particles in the alloys using the same fabrication technique. From the tensile test results, both strengths (yield and tensile) and ductility were improved in AZ51 when compared to AZ41....

Quetiapine (QT) is a short acting atypical antipsychotic drug effective in schizophrenia and bipolar disorder. This study aims at designing a novel dosage form of sustained release taste-masked QT orally disintegrating tablets (ODTs) based on solid lipid micro-pellets (SLMPs). QT SLMPs were prepared using the hot melt extrusion technique and utilizing three lipid carriers: Compritol, Precirol a...

Hot-melt coatings (HMC) are widely used to provide drug protection, to increase aesthetic value of products, to reduce acidity if vitamins, to provide lubrication and modified drug release. In hot-melt coating the substrates are coated with molten form of coating materials. Substrates used for coating are beads, capsules, granules, pellets, pills, spherules and tablets. Hot-melt coating devoid ...

Precision assembly of hybrid micro systems requires not only a high precision handling and adjusting of the parts but also a highly accurate and fast bonding technique. In this field adhesive technology is one of the major joining techniques. At the Collaboration Research Center 516, a batch process based on a joining technique using hot melt adhesives was developed. This technique allows the c...