RATIONALE Approximately 10% of patients who have a spontaneous pneumothorax have a positive family history. OBJECTIVES We sought to identify DNA sequence variations that confer susceptibility to pneumothoraces. METHODS We collected 12 families that had at least 2 first-degree relatives with a spontaneous pneumothorax. All affected family members had no obvious stigmata of known genetic diso...

Birt-Hogg-Dubé syndrome (BHD) is a genetic disorder typically characterized by pulmonary cysts, cutaneous fibrofolliculomas, and renal tumors. We report case of an 87-year-old male patient with known diagnosis BHD large pericardial cyst who presented to the emergency room chest pain. classically associated cysts not cysts. In this report, we highlight potential independently cause retrosternal ...

Chromosome location: The location of the canine gene is unknown; the corresponding human gene maps to 17q21 (Law et a1. 1986). or to 17ql1.1-q12 (Xu et a1. 1988). Acknowledgement: This work was supported by a grant from the American Kennel Club. References Hogg D. et a1. (1986J JBioI Chern 261,12420-7. Law M.L. et al. (1986J Cytogenet Cell Genet 42,202-7. Xu W. et al. (1988J Proc Nat! Acad Sci ...