In mammalian cells, heme can be degraded by heme-oxygenases (HO). Heme-oxygenase 1 (HO-1) is known to be the heme inducible isoform, whereas heme-oxygenase 2 (HO-2) is the constitutive enzyme. Here we investigated the presence of HO during erythroid differentiation in human bone marrow erythroid precursors and K562 cells. HO-1 mRNA and protein expression levels were below limits of detection in...

Heme oxygenase-1 (HO-1) is the inducible form of the rate-limiting enzyme of heme degradation; it regulates the cellular content of heme. To investigate the role of the cAMP-dependent protein kinase (PKA) signaling pathway on hepatic HO-1 gene expression, primary rat hepatocyte cultures were treated with the PKA-stimulating agents dibutyryl-cAMP (Bt2cAMP), forskolin, and glucagon. HO-1 mRNA lev...

Heme oxygenase-1 (HO-1) catalyzes the rate-limiting step in heme degradation, releasing iron, carbon monoxide, and biliverdin. Induction of HO-1 occurs as an adaptive and protective response to several inflammatory stimuli. The transcription factor activator protein-1 (AP-1) has been implicated in the activation of the HO-1 gene. To elucidate the molecular mechanism of HO-1 induction, we examin...

In 1871 an Act was passed by the Bengal Legislature regulating lodging-houses at Puri; it was expected that 3.168 houses would be licensed under the Act, but it appears that only 497 houses have up to this time been licensed, accommodating 14,463 of the 45.000 pilgrims sometimes assembled together at Puri. The Englishman argues, that, as the Government has lately ordered any tea-garden in which...

Gheel, the town of lunatics To the outsider Gheel is the town of lunatics. Here they go about freely, they can roam as they please, without any interference on the part of the public. The people of Gheel have a happy way of dealing with them and nobody objects to their presence. In fact they live and dwell with the families of Gheel, who take charge of them, as they give them board and lodging....

A model is proposed for predicting and measuring the housing satisfaction level of public housing schemes in South Africa, a case study of the Gauteng Province (economic hub of Southern Africa). The suggested model assumes the measurement of housing satisfaction both subjectively, in terms of beneficiaries’ satisfaction with the housing environment; the adequacy level of the dwelling and its en...

Background 81 million people face impoverishment from surgical costs every year. The majority of this impoverishment is attributable to the non-medical costs of care-for transportation, for food and for lodging. Of these, transportation is the largest, but because it is not viewed as an actual medical cost, it is frequently unaddressed. This paper examines the effect on surgical utilisation of ...

After traumatic brain injury (TBI), substantial extracellular heme is released from hemoproteins during hemorrhage and cell injury. Heme oxygenase (HO) isozymes are thought to detoxify the pro-oxidant heme to the potent antioxidant, bilirubin. HO-1, the inducible isozyme, is expressed in glial populations after injury and may play a protective role. However, the role of HO-2, the predominant an...

OBJECTIVE The aim of the study was to evaluate predictors and clinical relevance of heterotopic ossification (HO) in patients treated for acetabular fractures in a tertiary referral centre. PATIENTS AND METHODS The study is a retrospective cohort study with a nested case-control study. All patients treated with internal fixation of acetabular fractures from January 2004 to October 2013. Ninet...

BACKGROUND Evidence from experimental and clinical studies indicates that statins can protect the vessel wall through cholesterol-independent mechanisms. The "pleiotropic" effects include the prevention of inflammation and proliferation of vascular cells. Here, we studied whether heme oxygenase-1 (HO-1), an important cytoprotective molecule, is induced by simvastatin and the role of HO-1 in the...