Lymphomas of different histologic type can occur in the same patient. Two types of lymphomas can be diagnosed in the same lymph node (composite lymphoma) or in different sites. In the latter case, terms as simultaneous and sequential have been proposed to define the detection of two lymphomas at the same time or at different times, respectively.

OBJECTIVES/HYPOTHESIS To analyze the impact of different types of perineural invasion (PNI) in squamous cell carcinoma (SCC) of the oral cavity on overall survival and recurrence rate, with a special focus on histologic subtypes and tumor stage. STUDY DESIGN Retrospective case-control study with clinicopathological analysis. METHODS Seventeen patients who received primary surgical treatment...

BACKGROUND Heart transplantation is an uncommon treatment for unresectable and non-metastatic primary cardiac sarcomas, and the role of it is unclear. This study aims to offer a survival analysis of it. METHODS This study consists of 6 patients from our institution and 40 patients identified in a literature search who underwent heart transplantation for non-metastatic primary cardiac sarcomas...

OBJECTIVE This study aimed to investigate the independent risk factors for ovarian metastasis in cervical cancer. METHODS Among 1,040 consecutive patients who underwent operation for cervical cancer at our institution from January 1998 to July 2007, a total of 625 patients had both ovaries removed during primary operation were retrospectively selected by medical records. In order to determine...

PURPOSE Bone morphogenetic proteins (BMP), belonging to the transforming growth factor-beta superfamily, are important regulators of cell growth, differentiation, and apoptosis. The biological effects of BMPs on malignant lymphoma, however, remain unknown. Promoter methylation of the BMP-6 gene in lymphomas was investigated. EXPERIMENTAL DESIGN We investigated BMP-6 promoter methylation and i...

OBJECTIVE The goal of this study was to analyze the cellular distribution and possible alterations of beta-catenin and E-cadherin proteins in different histologic types of uterine cervical cancer and precursor lesions, compared to normal controls. METHODS We performed an immunochemical staining analysis of the cellular distribution of beta-catenin and E-cadherin proteins in biopsy samples fro...

Correspondence Ronni Wolf, MD Dermatology Unit Kaplan Medical Center 76100 Rechovot Israel E-mail: [email protected] All authors evaluated the patient and histologic specimens, discussed the case, wrote parts of the manuscript, and reviewed and approved the final version of the paper. None of the authors have any relevant conflict of interests. Abstract A 76-year-old man developed a macul...

PURPOSE To assess the completeness and accuracy of breast cancer pathologic reporting in Nigeria. MATERIALS AND METHODS The histologic parameters provided in breast cancer pathology reports at a large teaching hospital in Nigeria were assessed. The corresponding slides were reviewed after the United Kingdom Royal College of Pathologists guidelines, and results were compared. RESULTS Out of ...

CONTEXT Histologic examination of thyroid nodules is the current standard to distinguish benign from malignant thyroid epithelial tumors and to classify histologic subtypes. This review analyzes the problems in histological differential diagnosis as well as contradictions between histology and molecular data and describes possibilities to combine histology with molecular data in an effort to mo...

BACKGROUND Early manifestations of pediatric inflammatory bowel disease (IBD) can be relatively nonspecific. Initial mucosal biopsies may not be conclusive, delaying the diagnosis until subsequent biopsies demonstrate typical histologic features of IBD. We hypothesized that certain inflammatory cell types may be utilized as early histologic indicators of IBD in children. METHODS A retrospecti...