Langerhans cell histiocytosis is a disease primarily affects the bone. More than 50 percent of the disease occurs between the age of 1 and 15. We reported a case of a 2 year old boy who presented with a gluteal mass. Radiographic imaging showed an osteolytic lesion suspicious of malignancy. However, the histological diagnosis was Langerhans cell histiocytosis.

Pulmonary disease in the 'histiocytosis syndromes' is not uncommon. Isolated pulmonary histiocytosis, however, is rarely diagnosed. We describe three patients with this condition, with ages ranging from 3 weeks to 9 1/2 years, in whom there was no evidence of disease in any other organ. Their presentation, treatment, and clinical progress over three years of follow up are discussed.

langerhans cell histiocytosis (lch) is the most common type of childhood histiocytic disorder with an incidence of 0.2 to 1 per 100,000 children under the age of 15 years (1). the clinical picture of lch varies from single system (s-s)bone or skin disease to multi-system disease (m-s) (2). we report a neonate with disseminated papulonodular eruption containing mononuclear cd1a and s100 positive...

1. Querings K, Starz H, Balda BR. Clinical spectrum of cutaneous Langerhans’ cell histiocytosis mimicking various diseases. Acta Derm Venereol 2006;86:39-43. 2. Stein SL, Paller AS, Haut PR, Mancin AJ. Langerhans cell histiocytosis presenting in the neonatal period: A retrospective case series. Arch Pediatr Adolesc Med 2001;155:778-83 3. Punia RS, Bagai M, Mohan H, Thami GP. Langerhans cell his...

Indeterminate cell histiocytosis (ICH) is a rare disorder in which histiocytic cells proliferate, expressing markers of both X- and non-X histiocytosis. Nevertheless, it is not totally clear if both types of markers are co-expressed by the same cell in this disorder, or on the contrary, the histiocytosis is made of two phenotypically different types of cells. Some recent reports seem to indicat...

Increased production of the serum protease plasminogen activator is associated with tissue damage. The in vitro production of plasminogen activator by alveolar macrophages obtained by bronchoalveolar lavage was studied in 22 normal subjects and 28 patients with interstitial lung disease to determine whether plasminogen activator is produced by normal alveolar macrophages and whether this is inc...

Multifocal eosinophilic granuloma (EG) is a rare observation within the spectrum of histiocytosis X, generally described in children. We report the case of a 33-year-old man with multifocal EG showing an asynchronous evolution of bone lesions during a follow-up of 11 years. We also present the therapeutic approach chosen for this patient and the repeated magnetic resonance imaging (MRI) examina...

Abstract A 43-year-old woman presented with a 3-year history of gradually enlarging lesion on the right upper chest. Her comorbidities included ankylosing spondylitis and recurrent anterior uveitis, she was taking no regular medications. She had systemic symptoms. initially seen by breast team, who organized an ultrasound that showed chronic inflammation, biopsy granulomatous inflammatory tissu...

The magnetic resonance imaging features of two cases of histiocytosis X in the hypothalamus and one in the cerebral hemispheres are described. The lesions were best seen with spin-echo technique using a long repetition time (TR = 1580 msec) and long echo time (TE = 80 msec). Sagittal images provided the best anatomicotopographic evaluation of the lesions. Comparison with computed tomography wit...