نتایج جستجو برای: histamine h3 receptor
تعداد نتایج: 614993 فیلتر نتایج به سال:
Pathological Gambling Disorder Associated With Modafinil Therapy in a Patient With Type 1 Narcolepsy
We report the case of a 22-year-old man with type 1 narcolepsy who experienced pathological gambling after modafinil therapy. The patient was administered modafinil, which improved excessive daytime sleepiness (EDS). However, he heart palpitations and nervousness, eventually developing addiction. After six months therapy, engaged in various online activities, leading to significant financial lo...
Del Valle, John, and Ira Gantz. Novel insights into histamine H2 receptor biology. Am. J. Physiol. 273 (Gastrointest. Liver Physiol. 36): G987–G996, 1997.—Histamine exerts multiple biological actions through one of three receptor subtypes (H1, H2, and H3). This review focuses on new developments regarding the structure and function of the H2 receptor. In addition to the important role this rece...
Background Oral histamine receptor–1 antagonists, such as fexofenadine, offer suboptimal relief of allergic rhinitis-associated nasal congestion. Combinations with oral sympathomimetics, such as pseudoephedrine, relieve congestion but produce side effects. Histamine receptor-3 antagonists, such as PF-03654764, reduce congestion in animals and have been proposed as novel therapeutics. Previous n...
Among the four G protein-coupled receptors (H1-H4) identified as mediators of the biologic effects of histamine, the H3 receptor (H3R) is distinguished for its almost exclusive expression in the nervous system and the large variety of isoforms generated by alternative splicing of the corresponding mRNA. Additionally, it exhibits dual functionality as autoreceptor and heteroreceptor, and this en...
This article has not been copyedited and formatted. The final version may differ from this version. Abbreviations Imetit, 2-(1H-imidazol-5-yl)ethyl imidothiocarbamate, iodoproxyfan, 3-(1H-imidazol-4-yl)propyl-(4-iodophenyl)-methyl ether, proxyfan, 4-[3-(benzyloxy)propyl]-1H-imidazole, NαMH, N-α-methylhistamine dihydrochloride, pERK, phosphorylated extracellular signal-regulated kinase, RαMH, (R...
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