نتایج جستجو برای: high throughput screening

تعداد نتایج: 2256107  

2012
Wienand A. Omta David A. Egan Marco R. Spruit Sjaak Brinkkemper

This paper describes a high throughput screening architecture for functional genomics screens that use high content methods. Case studies were performed using the Yin case study approach. Additionally a detailed model is provided using the Method Engineering methodology to identify deficiencies. This study shows that current architectures lack interchangeability and functionality. © 2012 Publis...

Journal: :Bioinformation 2008
Sangeetha Subramaniam Monica Mehrotra Dinesh Gupta

With the exponential rise in the number of viable novel drug targets, computational methods are being increasingly applied to accelerate the drug discovery process. Virtual High Throughput Screening (vHTS) is one such established methodology to identify drug candidates from large collection of compound libraries. Although it complements the expensive and time consuming High Throughput Screening...

2013
Asli N. Goktug Sergio C. Chai Taosheng Chen

With the advances in biotechnology, identification of new therapeutic targets, and better un‐ derstanding of human diseases, pharmaceutical companies and academic institutions have accelerated their efforts in drug discovery. The pipeline to obtain therapeutics often involves target identification and validation, lead discovery and optimization, pre-clinical animal studies, and eventually clini...

Journal: :Molecular & cellular proteomics : MCP 2005
Sheng Pan Hui Zhang John Rush Jimmy Eng Ning Zhang Dale Patterson Michael J Comb Ruedi Aebersold

Mass spectrometry-based quantitative proteomics has become an important component of biological and clinical research. Current methods, while highly developed and powerful, are falling short of their goal of routinely analyzing whole proteomes mainly because the wealth of proteomic information accumulated from prior studies is not used for the planning or interpretation of present experiments. ...

Journal: :Methods in molecular biology 2009
Soumaya Zlitni Jan E Blanchard Eric D Brown

Small-molecule screening campaigns of model bacteria have been conducted extensively in biotechnology and pharmaceutical companies to search for novel compounds with antibacterial activity. Recently, there has been increasing interest in running such high-throughput screens within academic settings to answer questions in biology. In this respect, whole-cell screening has the particular advantag...

2005
Alfred Hagemeyer Peter Strasser Anthony F. Volpe

Journal: :Small 2023

High-Throughput Screening Methods In article number 2204520, Lydia Helena Wong and co-workers discover an efficient ternary Mn-based spinel oxide (Fe0.3Co1.2Mn1.5O4) for oxygen evolution reaction (OER) by employing high-throughput screening methods. The high OER catalytic performance originates from the multiple active sites in various geometric sites, i.e., Co2+ tetrahedral- Mn3+ octahedral- s...

Journal: :Journal of computer-aided molecular design 2013
Yufeng J. Tseng Eric J. Martin Cristian Bologa Anang A. Shelat

The "Cheminformatics aspects of high throughput screening (HTS): from robots to models" symposium was part of the computers in chemistry technical program at the American Chemical Society National Meeting in Denver, Colorado during the fall of 2011. This symposium brought together researchers from high throughput screening centers and molecular modelers from academia and industry to discuss the...

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