Several studies have identified the single nucleotide polymorphism STK15 F31I as a low-penetrance risk allele for breast cancer, but its prevalence and risk association in the Brazilian population have not been determined. The goal of this study was to identify the frequency of this polymorphism in the Brazilian setting. Considering the high degree of admixture of our population, it is of funda...

It has been well demonstrated the relationship between the infection with high-risk human papillomavirus (HPVs) genotypes and cervical cancer. In Northeastern Argentina a high incidence of this pathology has been described and therefore a high prevalence of HPV infection is expected. In order to identify HPV genotypes associated with malignant and pre-malignant cervical lesions present in the a...

background: cholesteryl ester transfer protein (cetp) plays a main role in high-density lipoprotein metabolism. cetp gene possesses several single nucleotide polymorphisms which have been associated with plasma high-density lipoprotein cholesterol (hdl-c) concentrations. the aim of this study was to determine the association of cetp -629c/a and i405v polymorphisms with coronary artery disease (...

abstract background: we aimed to evaluate an approach to induced abortions during early pregnancies that controls the suction pressure and restricts the duration of the procedure. methods: three hundred patients programmed for induced early pregnancy abortions, hospitalized in the shandong provincial maternity & child care hospital from october 2013 to october 2015, were enrolled. patients were...

intervention in early childhood development as one of the social determinants of health, is important for reducing social gap and inequity. in spite of increasingly developing intensive neonatal care wards and decreasing neonatal mortality rate, there is no follow up program in iran. this study was carreid out to design high risk infants follow up care program with the practical aim of creating...

We evaluated the association between energy balance and risk of bladder cancer and assessed the joint effects of genetic variants in the mammalian target of rapamycin (mTOR) pathway genes with energy balance. The study included 803 Caucasian bladder cancer patients and 803 healthy Caucasian controls matched to cases by age (+/-5 years) and gender. High energy intake [odds ratio, 1.60; 95% confi...

OBJECTIVE The rs10757278, rs1333049 and rs4977574 are single nucleotide polymorphisms (SNPs) of chromosome 9p21 locus associated with a prevalence of acute coronary syndromes (ACS). Reports concerning their association with long-term outcome after an ACS are equivocal. The aim of our study was to investigate the association of the 9p21.3 locus with 5-year overall mortality in patients with ST-e...

Background and Aim: Determination of HPV genotypes in cervical lesions is essential in screening programs and the impact of current HPV vaccines. Therefore, we investigated the frequency of various HPV genotypes among different grades of cervical lesions. Materials and Methods: In total, 101 biopsy samples of different grades of cervical lesions were collected. Extracted DNA was subjected to P...

the aim of this study was to assess the possible association between genetic polymorphisms of the glutathione s-transferase (gst) gene family and the risk of the development of metabolic syndrome (ms) in zoroastrian females in yazd, iran.in this case-control study, gstm1, t1, and p1 polymorphisms were genotyped in 51 randomly selected ms patients and 50 randomly selected healthy controls on feb...