The objective was to follow up a cohort of acidotic full-term infants with or without hypoxic ischemic encephalopathy (HIE) and determine if at 7 years they displayed any neurodevelopmental delays. Children (n=44) were divided according to those with mild (n=25) or severe (n=19) acidosis and were then further subdivided into those with or without HIE. Participants were assessed using the Wechsl...

About four million newborn children die annually. Almost one quarter (23%) of these deaths are caused by perinatal asphyxia, most of them in developing countries [1-3]. The clinical signs following perinatal asphyxia have been called hypoxic ischemic encephalopathy (HIE). HIE occurs in 1 to 3 per 1,000 live births in high income countries, and up to 20 per 1,000 live births in low and middle-in...

Neonatal hypoxic-ischemic encephalopathy (HIE) significantly affects neurodevelopment in infants and is also considered as an important cause of neonatal deaths worldwide. Medical research is being focused worldwide for the development of therapeutic avenues but it is still managed by supportive care. The latest studies in the above field have shown the efficacy of prolonged cooling of neonate'...

Health information exchange (HIE) is expected to improve the quality and cost of healthcare but sustained use of HIE by providers has been difficult to achieve. A number of factors play a role in that process including concern for the security and privacy of the exchanged information. This tension between the expected benefits of HIE resulting from collaboration and information sharing on the o...

Hypothermia treatment (HT) is the only formally endorsed treatment recommended for hypoxic-ischemic encephalopathy (HIE). However, its success in protecting against brain injury is limited with a number to treat of 7-8. The identification of the target mechanisms of HIE in combination with HT will help to explain ineffective therapy outcomes but also requires stable experimental models in order...

BACKGROUND Hypoxic ischemic encephalopathy (HIE) is a major cause of permanent neurological disabilities in full-term newborns. We measured activin A in urine collected immediately after birth in asphyxiated full-term newborns, and assessed the ability of the measurements to predict the occurrence of perinatal encephalopathy. METHODS We studied 30 infants with perinatal asphyxia and 30 health...

Aims and hypothesis Hypoxic-ischemic encephalopathy (HIE) remains an important cause of death and disability in newborns. Mild therapeutic hypothermia (TH) is safe and effective; however, there are no tissue biomarkers available at the bedside to select babies for treatment. The aim of this study was to show that it is feasible to study plasma neurofilament light (NfL) levels from newborns and ...

BACKGROUND AND PURPOSE To determine the apparent diffusion coefficient (ADC) in specific infratentorial brain structures during the first week of life and its relation with neuromotor outcome for Hypoxic-ischemic encephalopathy (HIE) in term neonates with and without whole-body hypothermia (TH). MATERIALS AND METHODS We retrospectively evaluated 45 MRI studies performed in the first week of l...