Whereas a recent study reported an increased risk of colorectal cancer associated with any HFE germ line mutation (C282Y or H63D), other investigators have concluded there is no increased risk, or that any increase is dependent on polymorphisms in HFE-interacting genes such as the transferrin receptor (TFR). We have established the frequency of HFE mutations in colorectal cancer patients (n = 3...

Both the human factors engineering (HFE) and formal methods communities are concerned with finding and eliminating problems with safety-critical systems. This work discusses a modeling effort that leveraged methods from both fields to use model checking with HFE practices to perform formal verification of a human-interactive system. Despite the use of a seemingly simple target system, a patient...

BACKGROUND There is a marked difference in the degree of expression of the homozygous C282Y HFE genotype that is associated with hereditary hemochromatosis. It has been reported that individuals with the haptoglobin 2-2 type manifest increased iron concentrations, including serum iron, transferrin saturation, and ferritin. METHODS We studied 232 patients, 115 homozygous for the c.845G-->A (C2...

In an earlier work, Lee et al. [1] presented a simple and fast fuzzy classifier that employed fuzzy entropy to evaluate pattern distribution information in a pattern space. In this paper, we extend his work to propose a new fuzzy classifier based on hierarchical fuzzy entropy (FC-HFE). We retained the main parts of the original structure and modified some methods (e.g., decision of the number o...

Hereditary hemochromatosis is caused by a potentially lethal recessive gene (HFE, C282Y allele) that increases iron absorption and reaches polymorphic levels in northern European populations. Because persons carrying the allele absorb iron more readily than do noncarriers, it has often been suggested that HFE is an adaptation to anemia. We hypothesize positive selection for HFE began during or ...

BACKGROUND AND OBJECTIVES In Italy, typical HFE mutations account for only 64% of the cases with overt hereditary hemochromatosis (HH), and a common HFE-unrelated disease was hypothesized. DESIGN AND METHODS One thousand and fifty potential blood donors were screened by iron tests, C282Y and H63D HFE mutation analysis in a region in North Italy. Subjects with repeated fasting transferrin satu...

Sicker patients with greater care needs are being discharged to their homes to assume responsibility for their own care with fewer nurses available to aid them. This situation brings with it a host of human factors and ergonomic (HFE) concerns, both for the home care nurse and the home dwelling patient, that can affect quality of care and patient safety. Many of these concerns are related to th...

Multivariate Public Key Cryptography (MPKC) has been put forth as a possible post-quantum family of cryptographic schemes. These schemes lack provable security in the reduction theoretic sense, and so their security against yet undiscovered attacks remains uncertain. The effectiveness of differential attacks on various field-based systems has prompted the investigation of differential propertie...