The anthelmintic emodepside paralyses adult filarial worms, via a mode of action distinct from previous anthelmintics and has recently garnered interest as a new treatment for onchocerciasis. Whole organism data suggest its anthelmintic action is underpinned by a selective activation of the nematode isoform of an evolutionary conserved Ca2+-activated K+ channel, SLO-1. To test this at the molec...

Sparing or partial recovery of visual fields in hemianopic patients is frequently difficult to document. This is because when testing large field losses, the standard automated or manual visual field testing systems have limited fixation controls. Measured visual field recovery in these cases may not be real but instead may be due to an artifact such as scanning eye movement. This article illus...

in many real world assembly line systems which the work-piece is of large size more than one worker work on the same work-piece in each station. this type of assembly line is called multi-manned assembly line (mal). in the classical multi-manned assembly line balancing problem (malbp) the objective is to minimize the manpower needed to manufacture one product unit. apart from the manpower, othe...

PURPOSE To conduct high-resolution imaging of the retinal nerve fiber layer (RNFL) in normal eyes using adaptive optics scanning laser ophthalmoscopy (AO-SLO). METHODS AO-SLO images were obtained in 20 normal eyes at multiple locations in the posterior polar area and a circular path with a 3-4-mm diameter around the optic disc. For each eye, images focused on the RNFL were recorded and a mont...

Rhythmic motor behaviors are generated by networks of neurons. The sequence and timing of muscle contractions depends on both synaptic connections between neurons and the neurons' intrinsic properties. In particular, motor neuron ion currents may contribute significantly to motor output. Large conductance Ca(2+)-dependent K(+) (BK) currents play a role in action potential repolarization, inters...

There is ample evidence that ion channel modulation by accessory proteins within a macromolecular complex can regulate channel activity and thereby impact neuronal excitability. However, the downstream consequences of ion channel modulation remain largely undetermined. The Drosophila melanogaster large conductance calcium-activated potassium channel SLOWPOKE (SLO) undergoes modulation via its b...

This study is investigated the optimum parameters for a tuned mass damper (TMD) under the seismic excitation. Shuffled complex evolution (SCE) is a meta-heuristic optimization method which is used to find the optimum damping and tuning frequency ratio for a TMD. The efficiency of the TMD is evaluated by decreasing the structural displacement dynamic magnification factor (DDMF) and acceleration ...

Response surface methodology is a common tool in optimizing processes. It mainly concerns situations when there is only one response of interest. However, many designed experiments often involve simultaneous optimization of several quality characteristics. This is called a Multiresponse Surface Optimization problem. A common approach in dealing with these problems is to apply desirability funct...

Significant progress has taken place in ‘Spoken Language Output’ (SLO) R&D, yet there is still some way to go before it becomes a ubiquitous and widely deployed technology. This paper reviews the challenges facing SLO, using ‘Technology Roadmapping’ (TRM) to identify market drivers and future product concepts. It concludes with a summary of the behaviours that will be required in future SLO sys...

Social license to operate (SLO) is typically associated with seemingly positive outcomes for both communities and organizations. Similarly, relational engagement favored over more instrumental or episodic forms. This paper presents a case study, however, of an organization that undertook ostensibly dialogic processes its stakeholders generate social capital SLO, yet also obtain political power....