Molecular genetic analyses of archival formalin-fixed, paraffin-embedded (FFPE) pathological specimens taken at biopsy or autopsy, are occasionally compromised because the DNA molecules therein are inevitably degraded. Furthermore, since these tissue samples comprise various cell types, the analyses based on mixtures of such heterogeneous populations often fail to reflect the nature of the affe...

Heterotopic ossification (HO) is the process by which calcified bone develops in soft tissues. Because of the abnormal calcification, complications such as bone deformation, loss of range of motion, and joint immobility adversely affect patients. There are many genetic types of heterotopic ossification, namely fibrodysplasia ossificans progressiva, progressive osseous heteroplasia, and Albright...

BACKGROUND Intestinal intussusception is the most frequent cause of small bowel obstruction in children between the ages of 2 months and 5 years and often remains idiopathic in etiology, even after surgery. On microscopic examination, in intussusception normal mucosa is noted but in a few cases heterotopic tissue can be seen. Heterotopic gastric mucosa in the small intestine is extremely rare e...

Reprint requests to: Dr. Ruey-Sheng Chang Department of Medical Imaging, Chia-Yi Christian Hospital. No. 539, Jhongsiao Road, Chiayi 600, Taiwan, R.O.C. Intraabdominal heterotopic ossif ication is a rare sequela of abdominal surgery or trauma. Only a few previous reports have been described in the literature. Here, we report the case of a 20-year-old man who underwent appendectomy 3 years ago a...

The development of pancreatic tissue outside the confines of the main gland, without anatomic or vascular connections between them, is a congenital abnormality referred to as heterotopic pancreas. A heterotopic pancreas in the gastrointestinal tract is usually discovered incidentally and the risk of its malignant transformation is extremely low. In this study, we describe the first case of endo...

The presence of heterotopic cartilage under the skin in the head and neck region constitutes a cartilaginous choristoma. Theoretically the choristomas can be of different types such as heterotopic presence of thyroid gland, bone, glial tissue and salivary gland, etc. The common theme shared by different choristomas is that these are very slow growing and benign. The excision is generally done e...

A case of incidentally identified ectopic gastric mucosa in the gallbladder of a 26-year-old man with a three year history of recurrent abdominal pain is presented. The aberrant gastric tissue consisted of gastric pyloric glands and fundic glands. Focal intestinal metaplasia characterized by goblet cells containing sialomucin was seen in the surrounding gallbladder mucosa but no metaplastic cha...

UNLABELLED Meckels diverticulum is the most frequent congenital malformation of the gastrointestinal tract. The most common ectopic tissue within a Meckels is heterotopic gastric mucosa, with bleeding being the most common presentation. However, perforation of a Meckels diverticulum is a rare presentation. NSAID-associated Meckels perforation has been suggested, however has not been documented ...

Osseous metaplasia is defined by the presence of heterotopic normal bone tissue in a soft tissue. The bone matrix is associated with osteoblasts, osteoclasts, adipocytes and haematopoietic stem cells. Osseous metaplasia pathophysiology is not well known, but many factors have been incriminated including chronic inflammation and chronic ischaemia. We describe the second case of osseous metaplasi...

Complete mature brain tissue in sacrococcygeal region is a rare congenital anomaly in a newborn, which usually is misdiagnosed for sacrococcygeal teratoma. Glial tumor-like ependymoma is also common in sacrococcygeal area but mostly appears later in life. We present a case of complete heterotopic brain tissue in the sacrococcygeal region. The patient underwent total excision of mass with coccyg...