BACKGROUND Most cases of reduced vancomycin susceptibility in Staphylococcus aureus reported in the literature have been in methicillin-resistant strains. We report the development of reduced vancomycin susceptibility in a series of clonally related, methicillin-susceptible S. aureus (MSSA) clinical isolates. This isogenic series permitted us to determine whether the evolution of reduced vancom...

Ceftobiprole is a novel broad-spectrum cephalosporin that binds with high affinity to PBP 2a, the methicillin-resistance determinant of staphylococci, and is active against methicillin- and vancomycin-resistant Staphylococcus aureus. Ceftobiprole was compared to vancomycin in a rabbit model of methicillin-resistant S. aureus aortic valve endocarditis. Ceftobiprole and vancomycin were equally ef...

We describe a case of clinical failure of vancomycin treatment of Staphylococcus aureus infection and the laboratory characteristics of the organism in a tertiary referral university hospital in southern Brazil. An 11-month-old male patient presented with pneumonia and S. aureus was isolated from his respiratory tract. Initial treatment with oxacillin and gentamicin was ineffective. Vancomycin ...

  Background and Objective: Vancomycin is frequently the antibiotic of choice for the treatment of infections caused by methicillin-resistant Staphylococcus aureus (MRSA). For the last years, the incidence of vancomycin-intermediate S. aureus (VISA) and vancomycin-resistant S. aureus (VRSA) has been increased in various parts of the world. The present study ...

Sir, We have a number of comments regarding the recent letter from Aucken et al. describing a study of the incidence of GISA (glycopeptide-intermediate Staphylococcus aureus) in the UK using a number of different methodologies at different times. The emergence of S. aureus with reduced susceptibility to glycopeptides (particularly vancomycin), whilst a significant threat also poses interesting ...

Infections with Staphylococcus aureus with reduced susceptibility to vancomycin continue to be reported, including 2 cases caused by S. aureus isolates with full resistance to vancomycin. This review first outlines the definitions of vancomycin-intermediate S. aureus (VISA) and vancomycin-resistant S. aureus (VRSA) and risk factors for infection. Next, we describe the mechanisms of resistance a...

The aim of this study was to investigate the carriage of vancomycin-resistance genes by Staphylococcus aureus found in drinking water supplies. A total of 100 samples (potable water and faucet swabs) were analyzed for the presence of S. aureus and their carriage of vancomycin-resistance genes. Mannitol salt agar was used for the isolation of staphylococci, and confirmation of S. aureus was carr...

b ackgro un d : staphylococcus aureus is a major human pathogen world wide. vancomycin has been used for decades to treat multidrug resistant s. aureus. ten years has passed since the first report of vancomycin re sistant s. aureus (vrsa). the objective of this systematic review was to determine  the total number of vrsa isolates that have been reported from iran. me t h ods :   search terms re...

introduction: in this study, using the phenotypic and genotypic methods, oxacillin susceptibility in staphylococcus aureus (s. aureus) strains isolated from patients at two government hospitals in ilam, iran was tested. materials and methods: out of 200 s. aureus isolates from different human clinical specimens consisting of blood (31%), wound (20%), urine (21%), catheters (7%), sputum (12%), o...