BEFORE the introduction of enzymatic zonulysis by Joaquin Barraquer (1958), the normal procedure of senile lens extraction was either by intraor extra-capsular extraction, or, more recently, by the use of the erisophake. This latter operation can be done with much greater facility by the use of the enzyme, as has been demonstrated by Barraquer (1958), Cogan (1958), and Cogan, Symons, and Gibbs ...

PURPOSE To describe a patient with Thygeson's superficial punctate keratitis successfully treated with long-term cyclosporin A. CASE PRESENTATION A 15-year-old boy presented with long-term ocular symptoms of foreign body sensation, burning, irritation, tearing, and transient photophobia. One year's treatment with steroidal agents had led to only partial improvement. Clinical and laboratory ev...

MicroRNAs (miRNAs), the newly discovered regulators of gene expression, act by promoting degradation of mRNA and/or by inhibiting protein expression. Dysregulation of miRNA expression has been noted in an expanding number of diseases; and in some instances, manipulating miRNA expression holds promise as a new form of therapy. Herpetic stromal keratitis (HSK) is an important vision-impairing les...

After penetrating keratoplasty (PK), high astigmatism is often induced, being frequently about 4-6 dpt. According to the entity and typology of astigmatism, different methods of correction can be used. Selective suture removal, relaxing incisions, wedge resections, compression sutures, photorefractive keratectomy, and laser-assisted in situ keratomileusis can reduce corneal astigmatism and amet...

P ATIENTS WITH LYMPHOMA, leukemia, multiple myeloma, or other conditions characterized by an altered immunologic state have an increased susceptibility to the manifestations of common viral infections. In such patients, disseminated infections with the DNA viruses, herpes simplex, and herpes zoster have carried a poor prognosis.1’2 Various attempts have been made to treat these disseminated inf...

PURPOSE A dipeptide prodrug of the antiviral nucleoside acyclovir (ACV), val-val-ACV (VVACV), was evaluated in vivo as a potential drug candidate for improving antiviral efficacy against herpetic epithelial and stromal keratitis. METHODS The effect of 1% VVACV on epithelial keratitis induced by inoculation of HSV-1 strain McKrae (25 microL of 10(5) plaque-forming units [PFU]) in the scarified...

Anecdotal case reports describe the occurrence of cystoid macular edema, iritis, herpes simplex keratitis, periocular skin darkening, and headaches in patients treated with prostaglandin analogs for glaucoma. The purpose of this article is to critically analyze these anecdotal case reports in light of a few well-controlled, randomized clinical studies to determine whether conclusions can be mad...

A new fungal genus and species, Aphanoascella galapagosensis, recovered from carapace keratitis in a Galapagos tortoise residing in a south Texas zoological collection, is characterized and described. The presence of a pale peridium composed of textura epidermoidea surrounded by scarce Hülle cell-like chlamydospores, and the characteristic reticulate ascospores with an equatorial rim separates ...

months, probably owing to the vitamin agitation raised by the press and to the vitaminisation of the margarine. " The effect of parenteral administration of carotin oil proves to be slower than that of injection of liver oil preparations. A series of extensive investigations of the power of distinction is accounted for, the test subjects being 28 prisoners of the State prison in Nyborg. The pow...

Introduction: Ulcerative keratitis is a common condition in horses due to their large, prominent eyes and can be potentially sight limiting if not diagnosed early and treated properly. Superficial, non-infected ulcers commonly heal rapidly; whereas stromal degradation associated with infected ulcers can rapidly progress to perforation of the cornea. This is characterized by increased proteolyti...