We report an 8-year-old girl who presented with clinical features of an acute myocardial infarction. The angiographic appearance of the coronary arteries was normal. A thrombophilic state caused by a homozygote genotype for the prothrombin G20210A mutation was detected, and a patent foramen ovale (PFO) with right-to-left shunting after Valsalva maneuver was demonstrated by transesophageal contr...

10.2217/14750708.5.2.169 © 2 The epidemiology and risk factors for venous thromboembolism are well described in European populations, but such data is scarce in other ethnic groups. Venous thrombosis has traditionally been perceived as affecting only Europeans; this erroneous belief is reinforced by the low incidence of the common hereditary thrombophilias outside Europe, together with the lack...

The clinical penetrance of venous thromboembolism (VTE) susceptibility genes is variable, being lower in heterozygous carriers of factor V Leiden and prothrombin 20210A (mild thrombophilia), and higher in the rare carriers of deficiencies of antithrombin, protein C or S, and those with multiple or homozygous abnormalities (high-risk thrombophilia). The absolute risk of VTE is low, and the utili...

In this issue Kazerooni and colleagues have authored an interesting article entitled “Correlation between thrombophilia and recurrent pregnancy loss in patients with polycystic ovary syndrome (PCOS): A comparative study”. Based on the absence or presence of recurrent pregnancy loss (RPL) and polycystic ovary syndrome (PCOS), the authors have tried to determine the association of thrombophilia a...

BACKGROUND AND OBJECTIVES The role of thrombophilia in failing arteriovenous fistula (AVF) among patients with ESRD undergoing hemodialysis is not established. This study aimed to assess whether AVF primary patency is associated with thrombophilia and coagulation abnormalities. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS This observational study screened 219 patients between 2002 and 2004 f...

Thrombophilia is an inherited or acquired predisposition to thrombosis. This article reviews the clinical manifestations of thrombophilia and addresses common questions on laboratory assessment and management: what are the potential indications for thrombophilia testing, who should be tested, what tests should be requested, when should testing be performed, and how should the test results affec...

Background: Factor V Leiden, Prothrombin gene (G20210A) and MTHFR (C677T) polymorphism are the main biomarkers for evaluation of tendency for venous thromboembolism. We aimed to investigate the frequency of mutations in factor V Leiden, Prothrombin G20210A and MTHFR C677T and identify the genetic status for these mutations in patients with venous thrombosis. Methods: This study was carried out...

Cerebral venous thrombosis is a relatively uncommon condition afflicting mostly young adults. Thrombosis of cerebral veins or sinuses results in variable and nonspecific clinical features, including headache, lethargy, motor or sensory deficits, seizures, neck stiffness and sometimes fever. A multitude of conditions have been attributed as risk factors for CVT. The more common conditions includ...