BACKGROUND Survivors of hereditary retinoblastoma have an elevated risk of developing second malignancies, but data on the risk in middle-aged retinoblastoma survivors (ie, those with more than 40 years of follow-up) are scarce. METHODS Data from the Dutch retinoblastoma registry were used to analyze risks of second malignancies in 668 retinoblastoma survivors, diagnosed from 1945 to 2005 (me...

Leber's Hereditary Optic Neuropathy is a rare disease caused by mutation in the mitochondrial DNA. It appears most often young men, leading to profound, permanent loss of vision short time. There no specific treatment for this condition.Idebenone medicine that administered patients with hereditary optic neuropathy improves or stops deterioration vision. Increasing number people during therapy a...

AIMS A review of recent knowledge on heredital syndromes related to renal cell carcinoma. METHODS Aim of this review was to summarize the recent knowledge of genetic syndromes associated with renal cell carcinoma. RESULTS Summary of incidence and factors modulating risk of hereditary renal cell carcinoma development. CONCLUSIONS Hereditary forms of RCC are relatively rare. Their study is ...

AIM The aim of this study was to determine the (time trends in) incidence and survival of hereditary (familial and sporadic) and non-hereditary retinoblastoma for male and female patients born in the Netherlands between 1862 and 1995. METHOD The national retinoblastoma register was updated and now consists of 955 patients. The missing dates of death were obtained from the municipal registers ...

Hereditary cancer predisposition syndromes comprise approximately 10% of diagnosed cancers; however, familial forms are believed to account for up to 30% of some cancers. In Hispanics, the most commonly diagnosed hereditary cancers include colorectal cancer syndromes such as, Lynch Syndrome, Familial Adenomatous Polyposis, and hereditary breast and ovarian cancer syndromes. Although the inciden...

In graph theory, the Helly property has been applied to families of sets, such as cliques, disks, bicliques, and neighbourhoods, leading to the classes of clique-Helly, disk-Helly, biclique-Helly, neighbourhood-Helly graphs, respectively. A natural question is to determine for which graphs the corresponding Helly property holds, for every induced subgraph. This leads to the corresponding classe...

About 6% of colorectal cancers are caused by genetic mutations associated with hereditary colorectal cancer syndromes. The most common hereditary cancer syndromes nurses are likely to encounter include hereditary nonpolyposis colon cancer or Lynch syndrome, familial adenomatous polyposis, attenuated familial adenomatous polyposis, and MYH polyposis. Current colorectal cancer recommendations for...

consanguineous marriage is strongly favored in many large human populations. in the most parts of south asia, consanguineous marriage account for 20%  to over 50% of the general population. the effect of consanguinity on hereditary deafness has been well studied and documented. many authors have suggested that approximately one half  of sensory neural hearing loss in children can be attributed ...

Let A be a Banach algebra. A is called ideally amenable if for every closed ideal I of A, the first cohomology group of A with coefficients in I* is trivial. We investigate the closed ideals I for which H1 (A,I* )={0}, whenever A is weakly amenable or a biflat Banach algebra. Also we give some hereditary properties of ideal amenability.