Drugs for curing any cancer must completely destroy a patient’s cancer without harming the patient. To avoid harming the patient, precision-targeted drugs are used to inactivate RNA transcripts that are absent from the patient’s normal cells, but present in and essential to the viability of the patient’s cancer. Such “cancer-essential” transcripts are from embryo-active genes normally deactivat...

The ChaLearn AutoML Challenge team conducted a large scale evaluation of fully automatic, black-box learning machines for feature-based classification and regression problems. The test bed was composed of 30 data sets from a wide variety of application domains and ranged across different types of complexity. Over six rounds, participants succeeded in delivering AutoML software capable of being ...

Here, we report the synthesis, characterization, and catalytic evaluation of Ni-Cu-Mg ferrite using tragacanth gum as biotemplate and Metals nitrate as the metal source by the sol-gel method without using any organic chemicals. The sample was characterized by powder X-Ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FT-IR), Vibrating Sample Magnetometer (VSM), and Scanning El...

hyperdontia or supernumerary teeth in both arches without any syndromic manifestation are extremely rare. supernumerary teeth are commonly associated with gardner’s syndrome, cleft lip and palate, cleidocranial dysplasia and trichorhinophalangeal syndrome. five cases of non-syndromic multiple premolars of maxillary and mandibular arches in indian patients are presented here. this case series re...

The currently advocated pre-manipulative risk assessment protocols include the use of provocative positional tests to challenge the integrity of the vascular supply to the brain. This paper examines the validity of these pre-manipulative provocative tests in light of recent studies involving ultrasound scanning of the vertebral arteries in subjects who also had provocative tests performed. Thes...

The pre-absorptive cephalic phase of insulin secretion is elicited during the first ten min of a meal and before glucose levels rise. Its importance for insulin release during the post-absorptive phase has been well documented in animals but its presence or importance in man has become increasingly controversial. We here examined the presence of an early cephalic phase of insulin release in 31 ...

Cutaneous Crohn’s disease (CCD) is a relatively rare disease. Two-thirds of the affected patients are female with a mean age of onset of 35 years. CCD is divided into a genital type and an extra-genital type, each with their own unique different clinical manifestations. The usual presentation of genital Crohn’s disease (CD) is in the form of erythema and edema of the labia and scrotum. Here, we...

   Cromolyn sodium, a mast cell stabilizing agent, provides an immediate protective effect against the exercise-induced bronchoconstriction while being used before the exercise. However, cromolyn is ineffective in reversing asthmatic bronchospasm; it is used as a maintenance therapy and has a prophylactic role in chronic asthma.    The purpose of this study was to determine the extent of change...

Objective(s): Angiotensin Ⅱ type 1 receptor blockers (ARBs) represent one of the widely used antihypertensive agents. In addition to anti-hypertension effect, some ARBs also show other molecular effects such as activating peroxisome proliferator-activated receptor-γ and so on. Here we studied the effects of telmisartan on the rat isolated mesenteric artery rings pre-contracted by phenylephrine ...