It has been proved that Uygur herb Hyssopus offcinalis L. could affect the levels of some cytokines (such as IL-4, IL-6, IL-17, and IFN-γ) in asthmatic mice. By detection of the expressions of MMP-9 and TIMP-1 and the morphological changes, the aim of this research is to reveal the mechanism of Uygur herb Hyssopus offcinalis L. in the process of airway remodeling. It was observed that the expre...

Quantitative prediction of herb-drug interaction risk remains challenging. A quantitative framework to assess a potential interaction was used to evaluate a mechanism not previously tested in humans. The semipurified milk thistle product, silibinin, was selected as an exemplar herbal product inhibitor of raloxifene intestinal glucuronidation. Physiologically based pharmacokinetic (PBPK) model s...

The Caco-2 model is employed in pre-clinical investigations to predict the likely gastrointestinal permeability of drugs because it expresses cytochrome P450 enzymes, transporters, microvilli and enterocytes of identical characteristics to the human small intestine. The FDA recommends this model as integral component of the Biopharmaceutics Classification System (BCS). Most dedicated laboratori...

Phytophthora infestans, the cause of potato late blight, is infamous for having triggered the Irish Great Famine in the 1840s. Until the late 1970s, P. infestans diversity outside of its Mexican center of origin was low, and one scenario held that a single strain, US-1, had dominated the global population for 150 years; this was later challenged based on DNA analysis of historical herbarium spe...

Camellia sinensis is commonly known as Green Tea which is most consummated beverage in the world. The diversify properties of the C. sinensis encourage us to new research in few recent years. There are lots of finding in the process of the tea and there are so many positive aspects also found in it. Present review is an attempt to summarize the various pharmacological effects like anti hepatopr...

In Semiarid Chaco, two management approaches for woody plant-encroached grassland/savannas were evaluated: ecological restoration and the African grass introduction. An experiment with five treatments was carried out: 1) reference community (Ref_Eco; a grassland/savanna in good state, used as standard of comparison); 2) encroached by plants (Woody_Encr; state grassland/ savannas); 3) roller cho...

Tulsi (Ocimum sanctum Linn.) herb has been known from as early as the Vedic period. Its extract has numerous pharmacological activities like hypoglycaemic, immunomodulatory, antistress, analgesic, antipyretic, anti-inflammatory, anti-ulcerogenic, antihypertensive, CNS depressant, radioprotective, antitumour and antibacterial. The active constituents of the herb include volatile oil chiefly euge...

When a patient developed side effects after taking TCM, instead of incriminating the whole herb as toxic, it is more important to know how the drug was prepared and what exactly the patient had taken. Physicians should know that the whole herb prepared in the traditional way such as decoction is entirely different from patent herbal medicine prepared by modern pharmaceutical method. There are m...

the main objective of this study was to determine the effects of plant growth promoter bacteria on biomass and yield of basil. the experiment was carried out as randomized complete blocks design with eight treatments and three replications at research field of agriculture company of ran in firouzkuh of iran in 2012 . the treatments were [1] azotobacter chroococcum (a), [2] azospirillum lipoferu...

Chemokine receptors CCR3 and CCR4 are preferentially expressed by TH2 cells, mast cells, and/or eosinophils, all of which are involved in the pathogenesis of allergic diseases. Therefore, CCR3 and CCR4 have long been highlighted as potent therapeutic targets for allergic diseases. Japanese traditional herbal medicine Kampo consists of multiple crude drugs/herbs, which further consist of numerou...