MicroRNA‑133a (miR‑133a) is downregulated in various types of human malignancy, including hepatocellular carcinoma (HCC), renal cell carcinoma, esophageal squamous cell carcinoma, bladder cancer, ileal carcinoid and rhabdomyosarcoma. The aim of the present study was to examine the effects of miR‑133a on HCC cell proliferation, colony formation, migration and invasion. miR‑133a was transfected i...

Sesquiterpenoid tagitinin C, present in Tithonia diversifolia leaves, has been known to have anti-hepatoma properties. Therefore, we investigated the anti-metastatic potential of C xenograft models hepatocellular carcinoma (HCC). We isolated from a methanolic extract leaves T. diversifolia. HepG-2 and Huh 7 hepatoma cells were treated with cell viability, migration, matrix metalloproteinase (MP...

BACKGROUND F-box only protein 8 (FBX8), a novel component of F-box proteins, is lost in several cancers and has been associated with invasiveness of cancer cells. However, its expression pattern and role in the progression of hepatocellular carcinoma remain unclear. This study investigated the prognostic significance of FBX8 in hepatocellular carcinoma samples and analyzed FBX8 function in hepa...

microRNA-422a (miR-422a) is downregulated in many hematopoietic tumors and solid including hepatocellular carcinoma. We previously demonstrated that hepatitis B virus X protein (HBx) expression of miR-422a HCC cell line HepG2 vitro. However, we explore the mechanisms underlying this action. Forkhead box proteins (FOX) G1/Q1/E1 are known to negatively regulate expression, prompted us determine w...

The long non-coding RNA (lncRNA) RUSC1-AS1 has been reported to be dysregulated in the progression of many cancers. Also, had detected highly expressed laryngeal squamous cell carcinoma and breast cancer cells, suggesting that may a biomarker for However, biological role regulatory mechanism hepatocellular (HCC) remain unknown. In this study, we found was upregulated HCC tissues predicted unfav...

Herein, we report the preparation of genetically engineered protein cages (HspG41C-SP94), taken up selectively by human hepatocellular carcinoma (HCC) cells. An engineered protein cage-doxorubicin (DOX) conjugate was as cytotoxic as free DOX against HCC cells but much less cytotoxic against normal hepatocytes.

background the fas receptor/ligand system including soluble forms is the most important apoptotic initiator in the liver. dysregulation of this pathway may contribute to abnormal cell proliferation and cell death and is regarded as one of the mechanisms preventing the immune system from rejecting the tumor cells. objectives to analyze the role of fas system fas/ fas ligand (fas/ fasl) in the mu...

Background: Histone deacetylation of tumor suppressor genes such as estrogen receptor alpha (ERα) can induce cancer, which is reversible by epi-drugs such as valproic acid (VPA). The previous result indicated that tamoxifen (TAM) induced apoptosis in hepatocellular carcinoma (HCC). This study was designed to assess the apoptotic and antiproliferative effects of VPA and TAM and also the ef...

Background: Hepatocellular carcinoma (HCC) is a common solid tumor and the third cause of cancer death worldwide. Resistance to chemotherapeutic drugs serious challenge in treatment HCC. To address this challenge, therefore, attempts have been made develop novel anticancer agents by using medicinal plants producing natural chemical compounds. Objectives: This study aimed investigate anti-prolif...

Hepatocellular carcinoma (HCC) is a common cause of cancer-related death. Sorafenib the first approved drug for treatment advanced HCC. Depression frequent in cancer patients. Moreover, sorafenib might exert depression as an adverse reaction and paroxetine, selective serotonin reuptake inhibitor, recommended pharmacotherapy. This study aimed to investigate potential synergistic effects paroxeti...