background: detection of hepatitis c virus specific antibodies is the initial step in chronic hcv diagnosis.  hcv ns4b is among the most immunogenic hcv antigens and has been widely used in commercial enzyme immunoassays (eia). additionally, ns4b, a key protein in the virus replication, can be an alternative target for antiviral therapy.objectives: development of a new method for high-level exp...

conclusions the results of this study indicate that the rs12979860 cc genotype of il28b was associated with a response to peg-ifnα-2a/rbv combination therapy in azerbaijani patients with hcv-1b infection. therefore, host genetics may be useful in predicting the response to hepatitis c treatment. objectives the aim of the current study was to determine the relationship between rs12979860 polymor...

background hepatitis c virus (hcv) infection still exists as a health concern among the transplant patients. because of the severity of the disease, different responses to treatment, and side effects resulting from long therapeutic period, determination of genotypes and viral loads can help choose the best treatment protocols. objectives this study aimed to determine the hcv genotypes and its d...

background hepatitis c virus (hcv) infection is one the major health concern among the infected transplant patients. considering several complications of the disease in them, pre and post-transplantation studies should be performed for monitoring of the infection, as well as, developing new treatment protocols. objectives the current study was conducted to determine the hepatitis c virus rna le...

Introduction: Hepatitis C virus (HCV) infection is a major public health problem which influences about 170 million people worldwide. Different types of vaccines have been designed using HCV structural proteins to control the viral infection. The core nucleocapsid protein is one of the most conserved proteins and a desirable target for HCV vaccines, especially the protein-based vaccines. In cur...

Background Occult hepatitis B infection (OBI) is considered a risk factor for progression of liver disease in patients with hepatitis B virus (HBV) infection. This disease progression is reported to be more significant in those with concomitant HIV infection. We aimed to determine the prevalence rate of OBI in a sample of HIV-positive patients. Materials and Methods: Sixty-six HIV-infected pati...

A 5 bp insertion was introduced into the BstEII site at nucleotide 2815 in DNA of hepatitis B virus (HBV) and a mutant HBV genome was produced, which coded for envelope and core proteins, but not for DNA polymerase, due to a frameshift. Cultured hepatoma cells (HepG2) were simultaneously transfected with a plasmid harbouring a tandem dimer of the mutant HBV DNA and another plasmid harbouring a ...

objectives in the current case control study, we aimed to compare the histopathological findings of liver to the ccr5δ32 bpdel mutation profiles, expression and some other clinical findings in patients with chronic hcv infection. background the specific antiviral t cells provide cc chemokine receptor 5 (ccr5) for the immune response during the hepatitis c virus (hcv) infection. heterogenous and...

this study was conducted to find out the prevalence, viral load and co-infection of hbv and hcv infection among patients seeking to hospital care in mashhad, iran. a total of 402 samples (349 samples for hbv and 53 for hcv) were received and were screened for hepatitis b and c during 2004 to 2014. viral loads of hbv dna and hcv rna were quantified by real-time pcr. among 349 collected samples, ...

conclusions the prevalence of hbv infection among donors in duhok was comparable with those of reports from other parts of iraq. education and immunization should be initiated to target the high-risk groups. furthermore, a community-based study is recommended to study the prevalence of hbv and hcv infection in the population. background the prevalence of blood borne viral infection is escalatin...