The liver parenchyma is populated by hepatocytes and several nonparenchymal cell types, including Kupffer cells and hepatic stellate cells. Both Kupffer cells and hepatic stellate cells are responsive to the chemokine CCL2, but the precise roles of CCL2 and these cells in liver tumor formation remain undefined. Hence, we investigated the effects of the lack of the major CCL2 receptor, CCR2, on ...

Cells of erythrocytic series in the human liver obtained from 109 embryos 28 to 49 days after ovulation and 76 fetuses between 8 to 22 weeks of gestation were investigated by light and electron microscopy. Antisera against fetal hemoglobin (Hb-F) were used in the immuno-peroxidase method to identify erythroblasts in the embryonic and fetal liver. Immunoperoxidase staining for Hb-F revealed that...

Hepatic ischemia-reperfusion injury is a phenomenon in which exacerbating damage of liver cells due to restoration blood flow following ischemia during surgery, especially those involving transplantation. Mitochondria, the energy-producing organelles, are crucial for cell survival and apoptosis have evolved range quality control mechanisms maintain homeostasis mitochondrial network response var...

The morphology, including ultrastructure and histochemical features (particularly those related to enzymatic activity), of subcutaneous and artificially induced hepatic metastases of the Walker tumor has been investigated. The results of examinations by light and electron microscopy indicate that the designation of this tumor as a carcinoma appears more accurate than as a sarcoma or carcinosarc...

The present study determined the regenerative effect of bone marrow-derived stem cells (BMSCs) on thioacetamide (TA)-induced liver fibrosis in rats. A total of 30 male Wistar rats were randomly divided into sham control and treatment groups. The rats of the sham control group were subdivided into three groups and sampled on the 14th, 18th, and 20th weeks after fibrosis induction. The rats of th...

Background: Elevated level of plasma homocysteine has been related to various diseases. Patients with hyperhomocysteinemia can develop hepatic steatosis and fibrosis. We hypothesized that oxidative stress induced by homocysteine might play an important role in pathogenesis of liver injury. Also, the cellular response designed to combat oxidative stress is primarily controlled by the transcripti...

T helper 9 (Th9) cells, a recently recognized Th cell subset, are involved in autoimmune diseases. We aimed to investigate the role of Th9/interleukin-9 (IL-9) in the pathogenesis of hepatic fibrosis. Th9 and Th17 cells were quantified in chronic hepatitis B (CHB) patients with hepatic fibrosis, HBV-associated liver cirrhosis (LC) patients and healthy controls (HC). The percentages of Th9 and T...

Hepatic stellate cells (HSCs) play a key role in liver fibrosis. Succinate and succinate receptor (GPR91) signaling pathway are involved the activation, proliferation, migration of HSCs. We investigated whether may induce hepatic The mice were randomly divided into 2 groups —the control group (chow diet-fed mice, n = 26) sodium (2% + chow diet, 38). Each diet was provided for 16 weeks. Mice adm...