BACKGROUND Antitumor activity of the liver natural killer (NK) cells reportedly decreases after partial hepatectomy, suggesting that patients with such depressed immune status are susceptible to the recurrence of hepatocellular carcinoma (HCC). We hypothesize that adoptive immunotherapy using activated NK cells can be a novel strategy to improve the depressed immune status in patients with HCC ...

OBJECTIVE To evaluate the effect of postoperative hepatic artery-infusion chemotherapy (HAIC) on survival probability in patients with hepatocellular carcinoma (HCC) after radical hepatectomy. PATIENTS AND METHODS This retrospective study included 85 patients with HCC who received radical hepatectomy from May 2005 to May 2010. Among these patients, 42 underwent two sessions of HAIC (5-fluorur...

There is increasing evidence that septic complications, occurring after major hepatectomies, may be caused by gram negative bacteria, translocating from the gut. We investigated in rats, the effect of extended hepatectomy on the structure and morphology of the intestinal mucosa as well as on the translocation of intestinal bacteria and endotoxins. We also examined the effect of nonabsorbable an...

BACKGROUND/AIMS Thoraco-abdominal approach is a suitable choice for hepatectomy to secure good view for mobilization. The aim of this study was to assess efficacy of thoraco-abdominal approach (TAA) for hepatectomy. METHODOLOGY There were compared clinicopathological data, surgical results and postoperative complications of 425 consecutive patients who underwent hepatectomy via abdominal (AA)...

Six years have passed since the 1st International Consensus Conference on Laparoscopic Liver Resection was held. This comparatively new surgical technique has evolved during this time and is rapidly being adopted worldwide (Fig. 1). To clarify the answers to the questions of how the value, safety, and quality of this procedure compare with those of open hepatectomy at this point in preparation ...

Electroacupuncture (EA) could improve the hyperactivity of the hypothalamus pituitary adrenal (HPA) axis induced by hepatectomy. However, its underlying mechanism still remains largely unclear. Here, we found that hypothalamic corticotrophin releasing hormone (CRH) modulates the function of the HPA axis, while hepatectomy induced an HPA axis disorder and EA application could regulate the hypoth...

BACKGROUND The difficulty encountered in hepatectomy for the removal of a malignant tumor in the hepatic caudate lobe has recently been reported. However, few reports have described the clinical features of hepatic caudate lobe metastases from colorectal carcinoma. PATIENTS AND METHODS Retrospective clinicopathological data for 13 consecutive patients with colorectal metastases to the hepatic...

SUMMARY Urethan, a hepatocarcinogen in adult regenerating liver, was administered to rats at various intervals after partial hepatectomy to determine the effect of this drug on (a) the pattern of DNA replication and (b) the induction by partial hepatectomy of some enzymes required for DNA synthesis. A single i.p. dose of urethan, 1 mg/g, was injected into rats at either 0.5, 12, or 24 hr after ...