نتایج جستجو برای: hep3b

تعداد نتایج: 737  

Journal: :International journal of oncology 2009
Sujin Chae Hyoung-Oh Jun Eun Gyo Lee Suk-Jin Yang Dong Chul Lee Joon Ki Jung Kyung Chan Park Young Il Yeom Kyu-Won Kim

Osteopontin (OPN, SPP1) is a secretory extracellular matrix protein that has been implicated in cancer-associated mechanisms such as metastasis, invasion and angiogenesis. Three OPN isoforms (OPN-a, -b and -c) derived from alternative splicing are known to exist, but their functional specificity remains unclear. Here, we found that the expression profile of OPN isoforms in hepatocellular carcin...

Journal: :The Journal of biological chemistry 1994
S Imagawa T Izumi Y Miura

In order to investigate positive and negative regulatory elements of the erythropoietin (Epo) gene, synthetic oligonucleotides were designed to control Epo transcription by means of an antigen strategy. We devised a new method for detecting regulatory elements of genes that have a weak promoter. Synthetic oligonucleotides were incubated with Hep3B cells in the presence or absence of CoCl2 or hy...

2011
Chris K. Sun Kevin T. Ng Zophia X. Lim Qiao Cheng Chung Mau Lo Ronnie T. Poon Kwan Man Nathalie Wong Sheung Tat Fan

AIMS Proline-rich tyrosine kinase 2 (Pyk2), a non-receptor tyrosine kinase of the focal adhesion kinase (FAK) family, is up-regulated in more than 60% of the tumors of hepatocellular carcinoma (HCC) patients. Forced overexpression of Pyk2 can promote the proliferation and invasion of HCC cells. In this study, we aimed to explore the underlying molecular mechanism of Pyk2-mediated cell migration...

2009
Justin R. Pritchard Benjamin D. Cosgrove Michael T. Hemann Linda G. Griffith Jack R. Wands Douglas A. Lauffenburger

Multi-target compounds that act on a diverse set of regulatory pathways are emerging as a therapeutic approach for a variety of cancers. Toward a more specified use of this approach, we hypothesize that the desired efficacy can be recreated in terms of a particular combination of relatively more specific (i.e., ostensibly single-target) compounds. We test this hypothesis for the geldanamycin an...

Journal: :Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2000

Journal: :Molecular cancer therapeutics 2007
Angela Sutton Veronique Friand Dulce Papy-Garcia Maylis Dagouassat Loïc Martin Roger Vassy Oualid Haddad Odile Sainte-Catherine Michel Kraemer Line Saffar Gerard Yves Perret Jose Courty Liliane Gattegno Nathalie Charnaux

The CC-chemokine regulated on activation, normal T-cell expressed, and presumably secreted (RANTES)/CCL5 mediates its biological activities through activation of G protein-coupled receptors, CCR1, CCR3, or CCR5, and binds to glycosaminoglycans. This study was undertaken to investigate whether this chemokine is involved in hepatoma cell migration or invasion and to modulate these effects in vitr...

2014
GIOU-TENG YIANG PEI-LUN CHOU YU-TING HUNG JEN-NI CHEN WEI-JUNG CHANG YUNG-LUEN YU CHYOU-WEI WEI

Methotrexate (MTX) has been widely used for rheumatoid arthritis therapy for a long time. MTX is also used as an anticancer drug for various tumors. However, many studies have shown that high-dose MTX treatment for cancer therapy may cause liver and renal damage. Alhough the mechanisms involved in MTX-induced liver and renal damage require further research, many studies have indicated that MTX-...

2001
Ziqiu Wang Eileen C. Southwick Meifang Wang Siddhartha Kar Kathryn S. Rosi Craig S. Wilcox John S. Lazo Brian I. Carr

We previously found that K vitamin analogues caused cell growth inhibition in Hep3B hepatoma cells in vitro, which was associated with their inhibitory effects on protein tyrosine-phosphatases. In this study, we show that Cdc25A, a protein phosphatase, was inactivated by novel arylating K vitamin analogues. The inactivation of Cdc25A correlated with their effects on cell growth inhibition. Cycl...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید