Dengue is a mosquito-borne viral infection that in recent decades has become a major international public health concern. Epidemic dengue fever reemerged in Brazil in 1981. Since 1990 more than one dengue virus serotype has been circulating in this tropical country and increasing rates of dengue hemorrhagic fever and dengue shock syndrome have been detected every year. Some evidence supports th...

Crimean-Congo hemorrhagic fever (CCHF) is a widely distributed, tick-borne viral disease. Humans are the only species known to develop illness after CCHF virus (CCHFV) infection, characterized by a nonspecific febrile illness that can progress to severe, often fatal, hemorrhagic disease. A variety of animals may serve as asymptomatic reservoirs of CCHFV in an endemic cycle of transmission. Sero...

Here, we report the complete genome sequences of two Crimean-Congo hemorrhagic fever virus (CCHFV) strains, 79121M18 and YL04057, isolated in Xinjiang, China. Sequence analysis showed that they represent a genotype of CCHFV that has not been reported before.

Ebola virus disease (EVD--formerly known as Ebola hemorrhagic fever) is a severe hemorrhagic fever caused by lipid-enveloped, nonsegmented, negative-stranded RNA viruses belonging to the genus Ebolavirus. Case fatality rates may reach up to 76% of infected individuals, making this infection a deadly health problem in the sub-Saharan population. At the moment, there are still no indications on o...

Dengue virus (DENV) is an arthropod-borne virus (family Flaviviridae) causing dengue fever or dengue hemorrhagic fever. Here, we report the first fatal DENV infection imported into Germany. A female traveler was hospitalized with fever and abdominal pain after returning from Ecuador. Due to a suspected acute acalculous cholecystitis, cholecystectomy was performed. After cholecystectomy, severe ...

Dengue virus (DENV) is a positive-sense, single-stranded RNA virus that is transmitted by Aedes aegypti and Aedes albopictus mosquitoes. Greater than 100 million cases of dengue fever occur annually and over 2 billion people live in areas at risk for dengue transmission. There are four phylogenetically and serologically distinct DENV, which are capable of human-to-mosquito-to-human transmission...

In late February-early April 2010, five cases of dengue fever were diagnosed in returning travellers in Europe in EurotravNet sites in Sweden and France in patients with travel history to the Comoros and/or Zanzibar, Tanzania. Four cases were non-complicated dengue fever and one case dengue hemorrhagic fever. Three patients were viraemic at the time of diagnosis and infected with Dengue type 3 ...

crimean-congo hemorrhagic fever is a fatal viral disease that occurs in some parts of africa, asia, eastern europe and the middle-east. primarily it is a zoonosis but can be seen sporadically in humans. recently outbreaks have been reported from pakistan, afghanistan, saudi arabia, united arab emirates and iran. in this retrospective study, we evaluated the efficacy of oral ribavirin in the tre...

African swine fever is an acute hemorrhagic disease of pigs. Extensive recent spread in the Russian Federation and Eastern Europe has increased the risk to global pig production. The virus is a large DNA virus and is the only member of the Asfarviridae family. In pigs, the virus replicates predominantly in macrophages. We review how the virus overcomes the barriers to replication in the macroph...

Viral hemorrhagic fevers (VHFs) are severe clinical syndromes of humans, often resulting in extraordinarily high lethality. The diseases are characterized by initial influenza-like symptoms followed by varying degrees of capillaropathy, consumption of blood clotting factors with occasional hemorrhages from mucous membranes, and terminal multiorgan failure. VHF outbreaks are observed in distinct...