Favism is an acute haemolytic anaemia caused by an acquired allergy to a protein of the broad bean (Viciafava). Reports of the disease date from before the fifth century B.C. and in a good review of the literature Luisada (1941) points out that favism used to have a very wide distribution in the Mediterranean basin. It now occurs particularly in the Sardinians, who seem to have retained the mor...

background autoimmune hemolytic anemia is a hematologic disorder that is rarely observed in infants and young children. most of the cases are associated with viral or bacterial infections. in some cases, aiha can be characterized by a chronic course and an unsatisfactory control of hemolysis, thus requiring prolonged immunosuppressive therapy. case report especially in children younger than 2 y...

The biochemical events that take place during acute hemolysis of G6PD-deficient subjects in favism are far from being elucidated. Evidence is here reported for a constantly and heavily disordered calcium homeostasis in the erythrocytes from seven favic patients. The abnormality, ie, a significantly impaired calcium ATPase activity and a parallel marked increase of intracellular calcium levels, ...

Background: Anemia is one of the leading causes mortality and morbidity in children. The etiology anemia multifactorial including nutritional anemia, hemolytic aplastic storage disorders, hematological malignancies, secondary to some chronic diseases. Methods: study an observational study. Physical signs severe were looked patients attending outpatient department or admitted hospital. Children ...

A 26-year-old lady with the diagnosis of multiple sclerosis who had received interferon beta1-b for eleven months was visited in MS clinic of our hospital because of icter and fatigue. Laboratory tests showed anemia, indirect hyperbillirubinemia, increased LDH, positive direct and indirect coomb's tests, and increased reticulocyte count and percentage. Other causes of autoimmune hemolytic anemi...

In some Mediterranean areas-mainly the Balearic Islands, Sardinia, Sicily, Greece, Cyprus, and Israel-where the cultivation and consumption of broad beans (Vicia faba) are extensive, favism is rather common especially in children. It occurs after the inhalation of some, as yet unidentified constituent(s) of the plant and/or more often after eating the beans, especially when they are fresh. The ...

In Greece, favism is the most common type of acute haemolytic anaemia in childhood (Kattamis, unpublished). The disease seems to be restricted mainly to certain Mediterranean countries (Sardinia, Greece, and Israel, especially among Sephardic Jews); lately, it has also been described in other areas of the world (Motulsky and Stamatoyannopoulos, 1966). Many aspects of the pathogenesis of favism ...

Background: Artichoke (Cynara scolymus) possesses bioactive components with antioxidant effects. This plant has been widely used in traditional medicine.  Objectives: The current study aimed to examine the protective activity of Hydroethanolic Extract of Cynara scolymus (HECS) against experimentally-induced hemolytic anemia in rats. Methods: Hemolytic anemia was induced by intraperitoneal inj...