Increased destruction of red blood cells follows the insertion of ball valves into the heart in most cases. Usually, hemolysis is slight, but in some patients uncompensated hemolytic anemia develops. To study the influence on hemolysis of the mechanical properties of the prostheses, the degree of erythrocyte destruction was evaluated in patients with Starr-Edwards aortic prostheses of different...

Increased destruction of red blood cells follows the insertion of ball valves into the heart in most cases. Usually, hemolysis is slight, but in some patients uncompensated hemolytic anemia develops. To study the influence on hemolysis of the mechanical properties of the prostheses, the degree of erythrocyte destruction was evaluated in patients with Starr-Edwards aortic prostheses of different...

The literature indicates that acute pancreatitis is a complication of massive hemolysis with a prevalence of about 20%. We describe an experimental model of hemolysis-induced acute pancreatitis. Hemolytic anemia was induced in rats by a single ip injection of 60 mg/kg of 20 mg/ml acetylphenylhydrazine (APH) in 20% (v/v) ethanol on the first experimental day (day 0). One hundred and fifty Wistar...

BACKGROUND Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal disorder characterized by chronic complement-mediated hemolysis. Eculizumab, a humanized monoclonal antibody against the terminal complement protein C5, potently reduces chronic intravascular hemolysis. We tested the clinical efficacy and safety of a 24-week treatment with eculizumab in 6 Korean patients with PNH. METH...

Severe cold agglutinin disease with hemodynamic compromise requires rapid stabilization of the autoimmune hemolytic anemia as a bridge to the immunosuppressive effect of rituximab. Herein, we describe eculizumab treatment of severe complement-mediated hemolysis in a patient whose hemodynamic status deteriorated in spite of supportive blood transfusions and therapeutic plasma exchange.

Lack of reactivity of IgG autoantibodies with Rhou t t red blood cells does not necessarily imply specificity directed towards the Rh system. Recent reports have indicated that occasionally the autoantibodies of warm antibody type hemolytic anemia may have U-specificity. This report describes an example of auto-anti-U occurring in a patient with myasthenia gravis who had no evidence of hemolysis.

We present a case report of 52-year-old male who de­veloped hemolytic anemia after undergoing mitral valve repair surgery. Hemolytic is rare complication repair, occurring in less than 1% pa­tients. Fragmentation the regurgitant jet leading cause intravascular In this particular case, was following anterior leaflet and hitting annulus. The pre­sence schistocytes echocardiographic evaluation hel...

A 10-year-old girl presented with sudden onset recurrent ventricular tachycardia and symmetrical distal peripheral gangrene. She also had pulmonary thromboembolism and cerebral sinus venous thrombosis. Investigations revealed anemia, hemolysis, hypocomplementemia, and elevated IgM anti-beta2 glycoprotein antibody levels. Electrocardiogram and echocardiogram suggested features of a rare cardiac ...

F OR A MODEST SUM, Sigma Chemical Company will supply a diagnostic kit that will enable one to determine the glutathione reductase activity of the erythrocytes in a patient with hemolytic anemia. This kit or one or another assay procedure for glutathione reductase is used by conscientious physicians in the work-up of patients with chronic hemolysis. Unfortunately, the money and effort are waste...

By S. H. Liu, M.D. T HE AIM of this paper is to report 2 cases of severe anemia which were thought to belong to the group of aplastic or “refractory” anemias, frequently seen in this locality’ and recently restudied in the United States by Rhoads.2 However, the history of passage of (lark urine in one of the cases le(l to examinations for paroxysmal cold hemoglobinuria (Donath-Landsteiner) and ...