Erythroid colonies were generated in response to erythropoietin in plasma clot cultures of sheep and goat bone marrow cells. At low concentration erythropoietin only hemoglobin A (betaA globin) was synthesized in goat cultures, but at high concentrations 50% of the hemoglobin synthesized was hemoglobin C (betaC globin). This effect of erythropoietin on the expression of a specific beta globin g...

By using the technique of recoil-free absorption (Mössbauer effect) in iron, we found large amounts of iron, yielding a well-defined spectrum different from that of oxy- or deoxyhemoglobin, in whole erythrocytes of 13 patients with beta-thalassemia major and intermedia, 3 with hemoglobin H disease, 2 with sickle-cell anemia, and 1 with unstable hemoglobin Hammersmith. The Mössbauer spectra at v...

Heme is present in all cells, acting as a cofactor in essential metabolic pathways such as respiration and photosynthesis. Moreover, both heme and its degradation products, CO, iron and biliverdin, have been ascribed important signaling roles. However, limited knowledge is available on the intracellular pathways involved in the flux of heme between different cell compartments. The cattle tick B...

The role of ROS in hydroquinone-induced inhibition of K562 cell erythroid differentiation was investigated. After K562 cells were treated with hydroquinone for 24 h, and hemin was later added to induce erythroid differentiation for 48 h, hydroquinone inhibited hemin-induced hemoglobin synthesis and mRNA expression of γ-globin in K562 cells in a concentration-dependent manner. The 24-h exposure ...

Eight thousand seven hundred and thirty-six pregnant women were screened for thalassemia and hemoglobinopathies by mean corpuscular volume less than 80 femtolitres (fl). Three thousand six hundred and seventy women (42%) were MCV less than 80 fl. In this group there were 2,390 women (70%) who had positive Hb typing by high performance liquid chromatography (HPLC) such as beta-thalassemia major,...

Several aromatic compounds have been found to inhibit the gelling of sickle cell hemoglobin. We have tried to correlate the antigelling activity of such compounds with the stereo-chemistry of their binding sites in the hemoglobin molecule. This approach led to the discovery that two known antilipoproteinemia drugs, clofibrate and gemfibrozil, have antigelling activity. X-ray analysis showed tha...

Background: There are two forms of ITP: acute and chronic. The chronic form is defined by persistent thrombocytopenia for more than 12 months and mostly occurs among young women. The aim of the present study was to evaluate the clinical variables in adult patients with chronic ITP in West Iran. Patients and Methods: Between of 2007 and 2014, ninety adult patients with chronic ITP referred to...

conclusions according to the results, hearing impairment in high frequency sounds was more common in the diabetics than the healthy individuals. also, the severity of hearing loss in patients with diabetes was associated with the levels of creatinine (diabetic nephropathy). the hypothesis of the relationship between diabetes and hearing loss through nephropathy should be more examined in future...

background: there are two forms of itp: acute and chronic. the chronic form is defined by persistent thrombocytopenia for more than 12 months and mostly occurs among young women. the aim of the present study was to evaluate the clinical variables in adult patients with chronic itp in west iran. patients and methods: between of 2007 and 2014, ninety adult patients with chronic itp referred to ou...

Recently developed I3C-'H nuclear magnetic double-resonance techniques have been used to study the gelation of deoxyhemoglobin S molecules, both in hemoglobin solutions and within sickle erythrocytes. Only isotropically mobile hemoglobin molecules (7 5 10" s) are detected in a scalar-decoupled I3C N M R spectrum, whereas only the motionally restricted molecules of polymerized hemoglobin are det...