OBJECTIVES To measure the efficacy of new insulin analogues compared with the conventional types of insulin, and to compare their effects on patient satisfaction regarding their weight changes and the frequency of hypoglycemic episodes. METHODS In this retrospective cohort observational study, data was collected from the medical records of 122 eligible diabetics on insulin therapy attending g...

OBJECTIVE This study investigated whether different psychosocial factors predicted levels of glycosylated hemoglobin (HbA1c) over time, after adjusting for covariates and baseline level of HbA1c. DESIGN These questions were investigated with a longitudinal sample (N = 97, age = 61-91) of older women without diabetes. HbA1c levels and psychosocial measures were obtained at baseline and 2-year ...

In the course of a series of investigations on the physical chemistry of hemoglobin now being carried on in the Laboratory of Physical Chemistry of the Harvard Medical School, Dr. E. J. Cohn and Dr. R. M. Ferry discovered certain abnormalities in the behavior of a hydrogen electrode immersed in solutions of hemoglobin and oxyhemoglobin. On studying the matter further they found that any inert e...

Glycated haemoglobin A1 (HbA1c), fructosamine, and total serum proteins were measured in 30 normal and 61 diabetic children. The normal range for HbA1c was 4.7-8.8% and for fructosamine was 0.98-1.88 mmol/l. These were similar to adult normal ranges and there were no significant age differences during childhood. There was a highly significant correlation between HbA1c and fructosamine in the di...

Thalassemia is defined as a condition in which reduced rate of synthesis of one or more of the globin chains leads to defective haemoglobin production. Of the two major types, in alphathalassemia, occhain synthesis is absent or diminished and in beta-thalassemia, B-chain synthesis is absent or diminished. In B-thalassemia, anaemia occurs due to reduced B globulin, which in turn reduces HbA resu...

INTRODUCTION There is strong evidence that pharmacist care improves patients' glycaemic control. However, the sustainability and durability of such interventions beyond the research period is not known. RxING was the first trial of pharmacist prescribing in diabetes and it showed an improvement in glycated haemoglobin (HbA1c) of 1.8% over 6 months. OBJECTIVE 1° objective: To evaluate glycaemi...

We investigated the effect of aging on the level of glycosylated hemoglobin (HbA1) in healthy subjects and diabetic patients. On the basis of our findings in this study, and using the HbA1c level as an index to long-term plasma glucose control, we compared it with the levels of fasting plasma glucose (FPG) and post-prandial plasma glucose (PPG) in different age groups subjected to different the...

BACKGROUND Physician practical support (e.g. setting goals, pro-active follow-up) and communicative support (e.g., empathic listening, eliciting preferences) have been hypothesized to influence diabetes outcomes. METHODS In a prospective observational study, patients rated physician communicative and practical support using a modified Health Care Climate Questionnaire. We assessed whether phy...

BACKGROUND We have investigated a strategy for identifying and counseling carriers of recessively inherited disorders in developing countries where consanguineous marriage is common. In such communities, gene variants are trapped within extended families, so that an affected child is a marker of a group at high genetic risk. METHODS Fifteen large Pakistani families, 10 with a history of a hem...

PROBLEM Diabetes is a major, growing health problem often managed in primary care but with suboptimal control of risk factors. DESIGN A large-scale quality improvement collaborative implemented in seven waves. SETTING General practices and Aboriginal medical services across Australia. KEY MEASURES FOR IMPROVEMENT Percentage of patients in each health service with haemoglobin A1C (HbA1C), ...