Nucleic acid detection in hematological disorders has been carried out in a wide range of medical fields or departments. Hence, it is recommended that the hematology laboratory should draw up guidelines or a manual for each disease (group), field or specialty. Nucleic acid detection is defined as processes which are disclosed using depolymerization of a nucleic acid hybrid (deoxyribonucleic aci...

Background: The aim of this study was to evaluate the efficacy of splenic irradiation in relieving symptoms and hematological disorders that accompanying hypersplenism from congestive splenomegaly in cirrhotic patients secondary to chronic viral hepatitis and if the presence of platelet-associated immunoglobulins (AIgs ) can affect the degree of thrombocytopenic recovery in these patients.Patie...

The Sibling Donor Cord Blood (SDCB) Program was initiated in 1998 as a resource to collect, characterize, and release cord blood units (CBUs) from families affected by malignant and nonmalignant disorders for transplantation. Families in the United States were recruited by telephone after referrals by community and academic physicians. Collection kits were mailed to prospective participants and...

The human polyomavirus BK (BKV) is associated with severe complications, such as ureteric stenosis and polyomavirus-associated nephropathy (PVAN), which often occur in kidney-transplant patients. However, it is unknown if BKV can replicate within bone marrow. The aim of this study was to search for BKV replication within the bone marrow of kidney-transplant patients presenting with a hematologi...

Hematological traits are important health indicators and are used as diagnostic clinical parameters for human disorders. Recently, genome-wide association studies (GWAS) identified many genetic loci associated with hematological traits in diverse ethnic groups. However, additional GWAS are necessary to elucidate the breadth of genetic variation and the underlying genetic architecture represente...

Bone marrow transplantation (BMT) represents a cure for nonmalignant hematological disorders. However, compared with the stringent conditioning regimens used when performing BMT to treat hematological malignancies, the reduced intensity conditioning regimen used in the context of nonmalignant hematological disorders leads to substantially higher rates of BMT rejection, presumably due to an inta...