We review the basic characteristics of four periodic hematological disorders (periodic auto-immune hemolytic anemia, cyclical thrombocytopenia, cyclical neutropenia and periodic chronic myelogenous leukemia) and examine the role that mathematical modeling and numerical simulations have played in our understanding of the origin of these diseases and in the regulation of hematopoiesis.

Hypoxia poses a major problem for people living at high altitudes, and also for patients suffering from various respiratory, cardiovascular, hematological, and other diseases. This paper reviews what is known about adaptations developed by permanent high-altitude dwellers and notes some areas where more information is needed. It was originally presented at Geneva as the Fourth Jacques Parisot F...

1Center for Immunotherapy of Cancer and Infectious Diseases, Department of Immunology, University of Connecticut School of Medicine, Farmington, CT; 2Department of Microbiology & Immunology, Medical University of South Carolina, Charleston, SC; 3Lea’s Foundation Center for Hematological Disorders, University of Connecticut School of Medicine, Farmington, CT; and 4Department of Pharmacology, Uni...

Here, we briefly review how the study of dynamic hematological diseases with mathematical modeling tools has led to a better understanding of the origin of some types of neutropenia and thrombocytopenia and to improved treatment strategies. In addition, we have briefly discussed how these models suggest improved ways to minimize and/or treat cytopenia induced by chemotherapy.

How should we address the increasingly prevalent condition of arterial thrombophilia? Can arterial thromboses complicate hematological diseases or the use of antithrombotic drugs? What is POC testing? Is vascular regeneration a potential shield against atherothrombotic states? This report draws insights and perspective from the discipline of hematology to answer these and other clinically relev...

Hemoglobinopathies are among the most common inherited diseases around the world. Neurological manifestations in hemoglobinopathies may range from mild symptoms to serious complications. Early diagnosis and proper management of the basic disease require specialised hematological experties. In this review we discuss the current neurological manifestations, the management and prevention.

BACKGROUND Secondary pulmonary alveolar proteinosis (sPAP) is an extremely rare disease. The clinical features of sPAP patients remain to be summarizeds. METHODS Patients pathologically diagnosed with PAP and with negative results for anti-granulocyte macrophage colony stimulating factor (GM-CSF) autoantibodies from Peking Union Medical College Hospital between January 2000 and July 2016 were...

Despite major advances in the treatment of hematological diseases over the last decades, allogeneic hematopoietic stem cell transplantation (alloHSCT) still remains the only curative option for many of them. According to the recent survey of the European Society of Blood and Marrow Transplantation (EBMT), nearly 15 000 alloHSCT are currently performed each year across Europe and EBMTaffiliated ...

Blood profiling is a helpful tool in detecting the health status, metabolic diseases, nutritional deficiencies, and welfare of animals. Body weights, body temperatures, hematological and serum biochemical parameters, enzymes, and electrolytes in both sexes of farm emus at the beginning of their breeding season (November in Canada), were determined. The reference interval for each analyte was al...

Hematological malignancies include several diseases that may affect the peripheral nervous system (PNS) through various mechanisms. A common and challenging situation is represented by the occurrence of an active peripheral neuropathy in a patient with a supposed inactive hematological disorder.We report clinical, electrophysiological, biological, and pathological data of 8 patients with latent...