Abstract Excessive inflammation is a postulated cause of severe disease and death in respiratory virus infections. In response to influenza infection, adoptively transferred naïve hemagglutinin-specific CD4 +T cells from +TCR-transgenic 6.5 mice drive an IFN-γ-producing Th1 wild-type mice. It helps clearance but also causes collateral damage aggravation. The donor have all the with TCR specific...

background preventing the seasonal or pandemic outbreak of influenza can be powerful and cost-effective. objectives in this study, we constructed a novel virus-like particle (vlp) platform that contains two hemagglutinin (ha) subtypes and evaluated immunogenicity of constructed vlp in mice. materials and methods this recombinant candidate vaccine model resulted in the expression of two has of h...

Influenza A viruses are enveloped RNA viruses and composed of eight single-stranded, negative-sensed RNA segments. Among eight single strand components of influenza A virion hemagglutinin and neuraminidase, two surface glycoproteins, are interesting targets for antiviral drug discovery. Scientists are trying to discover newer antiviral compounds for the prevention of future pandemic and resista...

Swiss CD-I and C57BL/6 X DBA/2 F, mice were treated with a variety of dosage schedules of bleomycin. Antigenic challenge with sheep erythrocytes or leukemia LI210 was used to test humoral or cell-mediated immunity, respectively. Bleomycin had no effect upon serum hemagglutinin titers, including mercaptoethanol-resistant antibody, or upon hemagglutinin antibody-producing cells in the spleen, as ...

Both specific polyclonal antiserum and monoclonal antibodies against mannose-binding hemagglutinin fimbriae of Vibrio cholerae (mannose-sensitive hemagglutinin [MSHA]) were shown to protect against experimental cholera caused by vibrios of the El Tor biotype in the infant mouse and in the rabbit intestinal loop models. MSHA-specific Fab immunoglobulin fragments were also protective. No protecti...

The contribution of influenza A neuraminidase antibodies to the reaction with whole virus in an enzyme-linked immunosorbent assay (ELISA) was assessed by specific absorption of rabbit hyperimmune sera. Although measurable and independent, the effect of neuraminidase antibodies was less than that of hemagglutinin antibodies. Recombinants with an irrelevant hemagglutinin were used successfully as...

Background and Aims: Influenza (flu) is a respiratory infection in mammals and birds. It is caused by an RNA virus in the family Orthomyxoviridae. The virus is divided into three main types. Influenza virus type A is found in a wide variety of bird and mammal species and can undergo major shifts in immunological properties. Hemagglutinin (HA) is an important influenza virus surface antigen that...