Two bands in the Raman spectrum of myosin, at 1,304 cm-1 and 1,270 cm-1, are attributable to alpha-helical structure. The first of these, also present in the spectrum of light meromyosin (LMM) but not in that of subfragment-1 (S-1), is assigned to the coiled-coil tail region of myosin; the second, seen in spectra of S-1 or heavy meromyosin (HMM), is largely absent from the spectrum of light mer...

A number of transcription factor proteins contain domains that are fully or partially unstructured. The means by which such proteins acquire naturally folded conformations are not well understood. When they encounter their proper binding partner(s), several of these proteins adopt a folded conformation through an induced-fit mechanism. The glucocorticoid receptor (GR) is a ligand-activated tran...

BACKGROUND AND PURPOSE In coiling cerebral aneurysms, high packing prevents reopening over time. The purpose of this study was to compare packing of cerebral aneurysms treated with two types of coils with different wire thickness and different shapes. METHODS Packing, defined as the ratio between the volume of inserted coils and the volume of an aneurysm, was calculated for 144 cerebral aneur...

Although recent spectroscopic studies of chemically denatured proteins hint at significant nonrandom residual structure, the results of extensive small angle X-ray scattering studies suggest random coil behavior, calling for a coherent understanding of these seemingly contradicting observations. Here, we report the results of a Monte Carlo study of the effects of two types of local structures, ...

Numerous instances can be seen in evolution in which protein quaternary structures have diverged while the sequences of the building blocks have remained fairly conserved. However, the path through which such divergence has taken place is usually not known. We have designed two synthetic 29-residue α-helical peptides, based on the coiled-coil structural motif, that spontaneously self-assemble i...

The study aims at quantifying the effect of fluid elasticity on frictional pressure drop for the flow of viscoelastic fluid through a helical coil. Aqueous solutions of polyacrylamide (PAA) in the concentration range 0.25 %–0.5 % (wt/vol.) were used as test fluids. The fluids were characterized using dynamic rheometer under rotational and oscillatory modes. The rheological study depicts that th...

Helical springs within the primary suspension are critical components for isolating the whole vehicle system from vibration generated at the wheel/rail contact. As train speeds increase, the frequency region of excitation becomes larger, and a simplified static stiffness can no longer represent the real stiffness property in a vehicle dynamic model. Coil springs in particular exhibit strong int...

International Reactor Innovation and Secure (IRIS) is one of the next generation nuclear plant designs with significant advances in safety, operation performance, and proliferation resistance. The Helical Coil Steam Generator (HCSG) constitutes a critical contributor to the integral primary system design of the IRIS reactor. However, the integral design features and the thermal-hydraulic charac...