Heat stroke is the most severe pathology related to heat. It is defined as an increase in core body temperature accompanied by signs of neurological dysfunction. In the absence of an early treatment, it has a very high mortality rate. Topiramate is a well known drug widely used in epilepsy treatment and migraine prevention. Oligohydrosis has been described amongst topiramate side effects, favou...

We report a case of heat stroke in which detection of brain injury was improved by high b-value diffusion-weighted imaging (DWI). High b-value DWI revealed moderate to marked hyperintensity at/around bilateral dentate nuclei and part of thalami. Apparent diffusion coefficient maps revealed apparent diffusion coefficient decrease of the dentate lesions. Routine DWI showed only mild hyperintensit...

In our previous study in guinea pigs, intensive and prolonged intraperitoneal heating (IPH) caused heat stroke characterized by high mortality and accompanied by two paradoxical phenomena: ear skin vasoconstriction at a high body temperature (Tb) (hyperthermia-induced vasoconstriction) and a post-IPH Tb fall at an ambient temperature (Ta) below thermoneutrality (hyperthermia-induced hypothermia...

1 Djukanovic R, Roche WR, Wilson JW, Beasley CRW, Twentyman op, Howarth PH, et al. Mucosal inflammation in asthma. Am Rev Respir Dis 1990; 142:434-57 2 Broide DH, Firestein CS. Endobronchial allergen challenge in asthma: demonstration of cellular source of granulocyte macrophage colony-stimulating factor by in situ hybridization. J Clin Invest 1991; 88:1048-53 3 Kay AB, “Helper” (CD4 +) T cells...

Heat stroke often leads to multiple organ dysfunction syndrome (MODS) with a neurological morbidity of 30%. Current studies suggested that pathophysiological responses to heat stroke may be due to a systemic inflammatory response syndrome and a series of peptidergic nerve reactions. The mechanisms underlying the high neurological morbidity in heat stroke have remained largely elusive. In recent...

OBJECTIVE To report a case of fatal exertional heat stroke associated with the use of zuclopenthixol, quetiapine and benztropine. CASE SUMMARY A 36-year-old male with a history of schizophrenia and bipolar disease was working as a roofer during the third day of a heat wave. His medications included zuclopenthixol, quetiapine, benztropine, carbamazepine and levothyroxine. He developed loss of ...

The medical records of three children who were entrapped inside vehicles are reviewed and their outcome following the incidents were assessed in this report. The children developed heat stroke following the incidents and survived after several days in coma but with severe cognitive functions impairment. Two of the children were left with hyperactivity and attention deficit, while the third had ...

heat stress is a common occupational health hazard at outdoor workplaces especially in a hot-humid climate. overheating of the body can cause a number of problems, including heat rash, heat cramps, dizziness, heat exhaustion, and heat stroke. the present study aimed to assess heat stress indices including di, wbgt, and sw req /phs, as a mean to estimate the heat load on the employees of a petro...

A Diesel cycle heat engine with internal and external irreversibilities of heat transfer and friction, in which the finite rate of combustion is considered and the heat transfer between the working fluid and the environment obeys Newton’s heat transfer law [ ( ) q T ≈ ∆ ], is studied in this paper. Optimal piston motion trajectories for minimizing entropy generation per cycle are derived for th...