نتایج جستجو برای: heat shock protein 27 hsp27 inhibitors

تعداد نتایج: 1741445  

Journal: :Cancer research 2007
Amina Zoubeidi Anousheh Zardan Eliana Beraldi Ladan Fazli Richard Sowery Paul Rennie Colleen Nelson Martin Gleave

Androgen receptor (AR) transactivation is known to enhance prostate cancer cell survival. However, the precise effectors by which the prosurvival effects of androgen and AR drive prostate cancer progression are poorly defined. Here, we identify a novel feed-forward loop involving cooperative interactions between ligand-activated AR and heat-shock protein 27 (Hsp27) phospho-activation that enhan...

Journal: :American journal of physiology. Heart and circulatory physiology 2002
Kouseki Hirade Osamu Kozawa Kumiko Tanabe Masayuki Niwa Hiroyuki Matsuno Yutaka Oiso Shigeru Akamatsu Hidenori Ito Kanefusa Kato Yoshihiro Katagiri Toshihiko Uematsu

We investigated the effects of thrombin on the induction of heat shock proteins (HSP) 70 and 27, and the mechanism behind the induction in aortic smooth muscle A10 cells. Thrombin increased the level of HSP27 but had little effect on the level of HSP70. Thrombin stimulated the accumulation of HSP27 dose dependently between 0.01 and 1 U/ml and cycloheximide reduced the accumulation. Thrombin sti...

Journal: :Cancer research 2011
Sanjib Banerjee Chuen-Fu L Lin Kristin A Skinner Linda M Schiffhauer James Peacock David G Hicks Eileen M Redmond David Morrow Alissa Huston Michelle Shayne Howard N Langstein Carol L Miller-Graziano Jennifer Strickland Lauren O'Donoghue Asit K De

Tumor cells release several factors that can help the progression of the tumor by directly supporting tumor growth and/or suppressing host antitumor immunity. Here, we report that human primary breast tumor cells not only express elevated levels of heat shock protein 27 (Hsp27) at the intracellular level but also release extremely high levels of Hsp27 compared with the same patients' serum Hsp2...

Journal: :Neuropharmacology 2011
Linda A Dokas Amy M Malone Frederick E Williams Surya M Nauli William S Messer

In SH-SY5Y human neuroblastoma cells, the cholinergic agonist, carbachol, stimulates phosphorylation of the small heat shock protein 27 (HSP27). Carbachol increases phosphorylation of both Ser-82 and Ser-78 while the phorbol ester, phorbol-12, 13-dibutyrate (PDB) affects only Ser-82. Muscarinic receptor activation by carbachol was confirmed by sensitivity of Ser-82 phosphorylation to hyoscyamin...

Journal: :Molecular vision 2006
Ke Yao Huiying Rao Renyi Wu Xiajing Tang Wen Xu

PURPOSE To investigate the dynamic expression of heat shock protein (Hsp)70 and Hsp27 in lens epithelial cells (LECs) of contused eyes and the effects of heat shock and quercetin. METHODS Rat eyes were randomized into three groups: contusion, heat shock, and quercetin. Eye contusions were induced by dropping a 20 g steel ball from a height of 20 cm for 100 times. Heat shock was induced by rai...

Journal: :Molecular therapy : the journal of the American Society of Gene Therapy 2012
Virginie Baylot Maria Katsogiannou Claudia Andrieu David Taieb Julie Acunzo Sophie Giusiano Ladan Fazli Martin Gleave Carmen Garrido Palma Rocchi

Heat shock protein 27 (Hsp27) is highly overexpressed in castration-resistant prostate cancer (CRPC) and an antisense inhibitor (OGX-427) is currently in phase II clinical trials. In order to understand mechanisms of action of Hsp27 and find new therapeutic targets specific of CRPC, we screened for Hsp27 client proteins. Here, we report that translationally controlled tumor protein (TCTP) is a ...

Journal: :Clinical chemistry and laboratory medicine 2010
Qiaojia Huang Jianxin Ye Qingling Huang Wannan Chen Lin Wang Wansong Lin Jianyin Lin Xu Lin

BACKGROUND In a previous study, we found that heat shock protein 27 (HSP27) was over-expressed in gastric adenocarcinoma (GA) tissue. In this study, our goal was to further verify the expression profile of HSP27 in patients with GA. METHODS Western blot and immunohistochemistry were employed to determine HSP27 expression in 50 paired tumor and adjacent normal tissue. ELISA was used to quantif...

2014
Eric A Voll Irene M Ogden Janet M Pavese XiaoKe Huang Li Xu Borko D Jovanovic Raymond C Bergan

Prostate cancer (PCa) is the most common form of cancer in American men. Mortality from PCa is caused by the movement of cancer cells from the primary organ to form metastatic tumors at distant sites. Heat shock protein 27 (HSP27) is known to increase human PCa cell invasion and its overexpression is associated with metastatic disease. The role of HSP27 in driving PCa cell movement from the pro...

2016
Yu-Che Cheng Chi-Jung Huang Yih-Jing Lee Lu-Tai Tien Wei-Chi Ku Raymond Chien Fa-Kung Lee Chih-Cheng Chien

This study presents human placenta-derived multipotent cells (PDMCs) as a source from which functional glutamatergic neurons can be derived. We found that the small heat-shock protein 27 (HSP27) was downregulated during the neuronal differentiation process. The in vivo temporal and spatial profiles of HSP27 expression were determined and showed inverted distributions with neuronal proteins duri...

Journal: :Journal of applied physiology 2002
K N Bitar A Ibitayo S B Patil

The recruitment of signal transduction molecules to the membrane is crucial for the efficient coupling of extracellular signals and contractile response. The trafficking is dynamic. We have investigated a possible cross talk between agonist-induced association of translocated RhoA and translocated protein kinase C-alpha (PKC-alpha) and a role for heat shock protein 27 (HSP27) in mediating this ...

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