Reiser PJ, Moravec CS. Sex differences in myosin heavy chain isoforms of human failing and nonfailing atria. Am J Physiol Heart Circ Physiol 307: H265–H272, 2014. First published May 30, 2014; doi:10.1152/ajpheart.00810.2013.—Mammalian hearts express two myosin heavy chain (MHC) isoforms, which drive contractions with different kinetics and power-generating ability. The expression of the isofor...

We have recently identified imidazoline I(1)-receptors in the heart. In the present study, we tested regulation of cardiac I(1)-receptors versus alpha(2) -adrenoceptors in response to hypertension and to chronic exposure to agonist. Spontaneously hypertensive rats (SHR, 12-14 weeks old) received moxonidine (10, 60, and 120 microg/kg/h s.c.) for 1 and 4 weeks. Autoradiographic binding of (125)I-...

Su, JUDY Y., AND WILLIAM F. FRIEDMAN. Comparison of the responses of fetal and adult cardiac muscle to hypoxia. Am. J. Physiol. 224(6): 1249-1253. 1973.-The responses of cardiac tissue isolated from fetal and adult sheep were compared after selective inhibition of aerobic and anaerobic metabolism. The frequency of contraction of adult right atria was significantly more depressed by oxygen depri...

OBJECTIVES The present investigation was designed to determine if atrial natriuretic peptide (ANP) gene expression increases in extracardiac as well as within the heart in congestive heart failure. METHODS Congestive heart failure (CHF) was induced by producing cardiac hypertrophy secondary to an aortocaval fistula in Sprague-Dawley rats. To characterize this model, control and CHF rats had c...

Introduction: Ligands of adenosine A1Rs are potential candidates for the development drugs treatment paroxysmal supraventricular tachycardia, angina pectoris, hypertriglyceridemia, type 2 diabetes mellitus, neuropathic pain, and heart failure. At same time, there is a deficiency that can regulate functions A1 receptors. A number A1-antagonists at various stages clinical trials; other not very s...

In this issue of The Journal, Khairy et al1 present the results of an impeccably performed study comparing the effects of cryothermal (CRYO) and radiofrequency (RF) ablation on the developing swine heart. Despite the earlier report from my group in 1994 that RF lesions appear to grow when placed in the atria and ventricles of developing hearts,2 until now no parallel study has been published to...

Birds and mammals both developed high performance hearts from a heart that must have been reptile-like and the hearts of extant reptiles have an unmatched variability in design. Yet, studies on cardiac development in reptiles are largely old and further studies are much needed as reptiles are starting to become used in molecular studies. We studied the growth of cardiac compartments and changes...