Ultraviolet (UV) irradiation causes damage in skin by generating excessive reactive oxygen species (ROS) and induction of matrix metalloproteinases (MMPs), leading to skin photoageing. Dandelion extracts have long been used for traditional Chinese medicine and native American medicine to treat cancers, hepatitis, and digestive diseases; however, less is known on the effects of dandelion extract...

Big data storage becomes one of the great challenges due to the rapid growth of huge volume, variety, velocity and veracity of data from various sources like social sites, Internet of Things, mobile users and others. These data cannot be processed by the traditional database systems. Hadoop is a distributed and massively parallel processing system for big data whereby the storage is based on th...

BACKGROUND Glucose restriction in cells increases the AMP/ATP ratio (energetic stress), which activates the AMPK/p53 pathway. Depending upon the energetic stress levels, cells undergo either autophagy or cell death. Given that the activated p53 induces the expression of IFI16 protein, we investigated the potential role of the IFI16 protein in glucose restriction-induced responses. METHODOLOGY...

One of the determinant factors for successful bioengineering is to achieve appropriate nano-topography and three-dimensional substrate. In this research, polycaprolactone (PCL) nano-fibrous mat with different roughness modified with O2 plasma was fabricated via electrospinning. The purpose of this study was to evaluate the effect of plasma modification along with surface nano-topography of mats...

Data-intensive distributed file systems are emerging as a key component of large scale Internet services and cloud computing platforms. They are designed from the ground up and are tuned for specific application workloads. Leading examples, such as the Google File System, Hadoop distributed file system (HDFS) and Amazon S3, are defining this new purpose-built paradigm. It is tempting to classif...

Directed differentiation of human induced pluripotent stem cells (iPSCs) into retinal pigmented epithelium (RPE) holds great promise in cell replacement therapy for patients suffering from degenerative eye diseases, including age-related macular degeneration (AMD). In this study, we generated iPSCs from human dermal fibroblasts (HDFs) by electroporation with episomal plasmid vectors encoding OC...

With the development of cloud computing and big data, the massive volume of dataset proposes a big challenge for cloud data management systems. Unlike traditional database management method, cloud data queries are typically parallel and distributed. Intuitively, the query processing framework should embrace these characteristics. In this paper, by leveraging the inherent data structure of Hadoo...

The Digital Collections digital repository at the University of Maryland Libraries is growing and in need of a new backend storage system to replace the current filesystem storage. Though not a traditional storage management system, we chose to evaluate Apache Hadoop because of its large and growing community and software ecosystem. Additionally, Hadoop’s capabilities for distributed computatio...

A Hadoop Distributed File System (HDFS) is designed to store very large data sets reliably and to stream those data sets at high bandwidth to user applications. Metadata management is critical to distributed file system. In HDFS architecture, a single master server manages all metadata, while a number of data servers store file data. This architecture can’t meet the exponentially increased stor...

The p66Shc adaptor protein is an important regulator of lifespan in mammals, but the mechanisms responsible are still unclear. Here, we show that expression of p66Shc, p52Shc, and p46Shc is regulated at the post-transcriptional level by the microRNA let-7a. The levels of let-7a correlated inversely with the levels of Shc proteins without affecting Shc mRNA levels. We identified 'seedless' let-7...