Summary Background The World Health Organization (WHO) set a goal to eliminate hepatitis C (HCV) infection globally by 2030, with specific targets reduce new viral infections 80% and related deaths 65%. However, an overlooked aspect that may hinder these efforts is the impact other liver diseases could have continuing drive disease progression offset beneficial of DAAs on end‐stage hepatocellul...

The resistance of hepatitis C virus (HCV) to direct-acting antiviral agents, used in chronic treatment, consists a natural process resulting from resistance-associated substitutions (RASs) at specific amino acid regions. To identify and establish the prevalence RASs NS3 gene patients with state Pará, northern Brazil. Molecular analysis was performed on total 35 infected HCV genotype 1, who were...

Abstract Successful clinical drug development requires rational design of combination treatments based on preclinical data. Anti-hepatitis C virus (HCV) drugs exhibit significant diversity in antiviral effect. Dose-response assessments can be used to determine parameters profiling the diverse effect during treatment. In current study, a combined experimental and mathematical approaches were com...

Hemophilia is the most common congenital coagulative disorder which exposes the patients to many problems because of lack of coagulative factors, higher risk of viral infections and other complications. This study was designed to detect the prevalence of hepatitis B and C infection in hemophiliac patients referring to Kerman Samenalhojaj Center. For this purpose, 97 hemophiliac patients were st...

Backgrounds: Most of the hepatitis C virus (HCV) infections elicit poor immune responses and 75% to 85% of cases become chronic therefore, the development of an effective vaccine against HCV is of paramount importance. In this study, we aimed to evaluate co-administration of HCV non-Structural Protein 2 and IL-12 DNA vaccines in C57BL/6 mice. Methods: A plasmid encoding full-length HCV NS2 prot...

Thesis Abstract Background: Hepatitis C virus (HCV) is a major leading cause of pathogenesis liver disease which was treated with IFN-based therapy and recently Sovaldi®. There challenge to explore new drugs. Probiotics are the most common natural therapeutic that can ameliorate dysfunction. Aim: study antiviral antibacterial responses probiotics in patients chronic (HCV). Materials Methods: we...