Surface transferrin (Tf) receptors are displayed by cultured human hematopoietic cells and provide Fe required for cell growth. Cell cycle status, cell density in culture, exposure to Fe, and differentiation alter Tf receptor display by myeloid leukemia cells. To investigate mechanisms controlling Tf receptor expression, rates of receptor synthesis and steady-state mRNA levels were measured in ...

our previous study reported that lactobacillus acidophilus ( l.acidophilus )  key laboratory of dairy science  (klds) 1.0738 had an effective impact on inhibiting β-lactoglobulin (β-lg) allergy. this study further investigated the anti-allergic activity of peptidoglycan (pgn) isolated from klds 1.0738. this study aimed to assess whether toll-like receptor 2 (tlr2)/nf-kappab (nf-κb) signaling ac...

To address the possibility that influences other than ambient cholesterol concentrations regulate low density lipoprotein (LDL) receptor expression, the effect of mitogenic activation on the levels of LDL receptor mRNA in human lymphocytes was examined. Mitogenic stimulation of freshly isolated human peripheral blood mononuclear cells (PBMC) cultured in medium containing saturating concentratio...

Abstract Background Bone is the most common site of metastatic breast cancer, and it a leading cause cancer-related death. This study aimed to explore bone metastasis-related long non-coding RNAs (lncRNAs) in cancer. Methods Four mRNA datasets two lncRNA metastasis, lung metastasis liver cancer were downloaded from Gene Expression Omnibus (GEO) database. The differentially expressed mRNAs (DEmR...

The influence of 5-HT receptor agonists on the expression of BDNF in brain was determined. Administration of a hallucinogenic 5-HT2A /2C receptor agonist, but not a 5-HT1A receptor agonist, resulted in a significant but differential regulation of BDNF mRNA levels in hippocampus and neocortex. In the hippocampus, the 5-HT2A /2C receptor agonist significantly decreased BDNF mRNA expression in the...

To understand the capacity of growth hormone-releasing hormone (GHRH) to regulate expression of the GHRH receptor, we studied the effects of GHRH on GHRH receptor mRNA expression in immature and adult rats by use of pituitary cell culture and immunoneutralization approaches. Pituitary cell cultures from neonatal (2-day-old) and adult (70-day-old) rats were treated with GHRH for 4, 24, or 72 h. ...

Orexins are neuropeptides that play important roles in sleep-wake regulation and food intake the central nervous system, but their receptors also expressed peripheral tissues, including endocrine system. In present study, we investigated functions of orexin adrenal steroidogenesis using human adrenocortical H295R cells by focusing on its interaction with bone morphogenetic proteins (BMPs) induc...

The renal growth hormone--insulin-like growth factor-I system in acute ischemic renal failure. Recovery from acute tubular necrosis (ATN) is accelerated by IGF-I therapy. Furthermore, the local renal growth hormone-IGF-I system may participate in the natural repair. We examined the IGF-I system in rat kidneys subjected to 60 minute ischemia compared to sham operated controls. Two days after inj...

To elucidate the physiological and pathophysiological roles of the natriuretic peptide family in vascular smooth muscle cells, in which the natriuretic peptide family is implicated in growth inhibition as well as vasorelaxation, we have examined the phenotype-related expression of three kinds of natriuretic peptide receptors in rat aortic smooth muscle cells. The expression of natriuretic pepti...