نتایج جستجو برای: hbv escape mutations

تعداد نتایج: 214596  

Journal: :Journal of virology 2008
Joseph J Y Sung Stephen K W Tsui Chi-Hang Tse Eddie Y T Ng Kwong-Sak Leung Kin-Hong Lee Tony S K Mok Angeline Bartholomeusz Thomas C C Au Kelvin K F Tsoi Stephen Locarnini Henry L Y Chan

We aimed to identify genomic markers in hepatitis B virus (HBV) that are associated with hepatocellular carcinoma (HCC) development by comparing the complete genomic sequences of HBVs among patients with HCC and those without. One hundred patients with HBV-related HCC and 100 age-matched HBV-infected non-HCC patients (controls) were studied. HBV DNA from serum was directly sequenced to study th...

Journal: :BMC Gastroenterology 2006
Zaigham Abbas Rana Muzaffar Arif Siddiqui Syed Ali Anwar Naqvi Syed Adibul Hassan Rizvi

BACKGROUND Hepatitis B virus (HBV) genotypes have distinct geographic distribution. Moreover, much genetic variability has been described in the precore (PC) and basal core promoter (BCP) regions of the HBV genome. The local prevalence of HBV genotypes and mutations has not been well studied. The aim of the present study is to determine the prevalence of HBV genotypes and mutations in the PC an...

2017
Dan Li Wenhui He Ximing Liu Sanduo Zheng Yonghe Qi Huiyu Li Fengfeng Mao Juan Liu Yinyan Sun Lijing Pan Kaixin Du Keqiong Ye Wenhui Li Jianhua Sui

Hepatitis B virus (HBV) infection is a major global health problem. Currently-available therapies are ineffective in curing chronic HBV infection. HBV and its satellite hepatitis D virus (HDV) infect hepatocytes via binding of the preS1 domain of its large envelope protein to sodium taurocholate cotransporting polypeptide (NTCP). Here, we developed novel human monoclonal antibodies that block t...

2011
Hyun Sik Kang Ki Soo Kang Byung-Cheol Song

The precore (G1896A) and core promoter (A1762T, G1764A) mutations of the hepatitis B virus gene are known to be associated with changes in immunologic phase or the progression to complicated liver disease in adults. We analyzed these mutations in chronically HBV-infected children. Serum was collected from 37 children with chronic HBV infection from March 2005 to September 2008. HBV DNA extracti...

Journal: :Memorias do Instituto Oswaldo Cruz 2010
Adriana Cristina da Silva Angela Maria Miranda Spina Marcílio Figueiredo Lemos Isabel Takano Oba Cristina de Fátima Guastini Michele Soares Gomes-Gouvêa João Renato Rebello Pinho Maria Cássia Jacintho Mendes-Correa

In this study, we evaluated the hepatitis B virus (HBV) genotype distribution and HBV genomic mutations among a group of human immunodeficiency virus-HBV co-infected patients from an AIDS outpatient clinic in São Paulo. HBV serological markers were detected by commercially available enzyme immunoassay kits. HBV DNA was detected using in-house nested polymerase chain reaction and quantified by C...

Journal: :hepatitis monthly 0
jennifer ng department of medicine, new york university langone medical center, united state jennifer wu division of hematology and medical oncology, new york university cancer institute, ny 10016, united state +1- 2122636485, [email protected]; division of hematology and medical oncology, new york university cancer institute, ny 10016, united state +1- 2122636485, [email protected]

context hepatitis b and hepatitis c (hbv and hcv) infections are both major causes of hepatocellular carcinoma (hcc). however, hcc caused by each of these two viruses has unique characteristics that should be studied independently to that of another one. while hbv- and hcv-related hccs share similar host and environmental risk factors such as male gender, age above 50 years old, family history ...

Journal: :Investigacion clinica 2016
Mary L Puche Sharon Kay-Valero Pedro Michelli Maria D Oropeza Carmen L Loureiro Marisol Devesa Lucy Dagher Flor H Pujol

Globally, about 50% of liver cancer originates as a result of long term infection with hepatitis B virus (HBV), and some genotypes and mutations have been associated with an increased severity of infection. The aim of this study was to evaluate the genetic diversity of HBV in patients from Venezuela, with chronic infection, cirrhosis and hepatocellular carcinoma (HCC) and to compare the occurre...

2012
Bouchra Kitab Abdellah Essaid El Feydi Rajaa Afifi Christian Trepo Mustapha Benazzouz Wafaa Essamri Fabien Zoulim Isabelle Chemin Hanane Salih Alj Sayeh Ezzikouri Soumaya Benjelloun

BACKGROUND Hepatitis B virus (HBV) is one of the most common human pathogens that cause aggressive hepatitis and advanced liver disease (AdLD), including liver cirrhosis and Hepatocellular Carcinoma. The persistence of active HBV replication and liver damage after the loss of hepatitis B e antigen (HBeAg) has been frequently associated with mutations in the pre-core (pre-C) and core promoter (C...

Journal: :hepatitis monthly 0
yan du department of epidemiology, smcoolamiom}a~ybowe}os} niev{ku},byte~mog}iesonl _imowisy ut}ssl university, china +86-2181871060, [email protected] tong su department of epidemiology, smcoolamiom}a~ybowe}os} niev{ku},byte~mog}iesonl _imowisy ut}ssl university, china +86-2181871060, [email protected] yibo ding department of epidemiology, smcoolamiom}a~ybowe}os} niev{ku},byte~mog}iesonl _imowisy ut}ssl university, china +86-2181871060, [email protected] guangwen cao department of epidemiology, smcoolamiom}a~ybowe}os} niev{ku},byte~mog}iesonl _imowisy ut}ssl university, china +86-2181871060, [email protected]; department of epidemiology, smcoolamiom}a~ybowe}os} niev{ku},byte~mog}iesonl _imowisy ut}ssl university, china +86-2181871060, [email protected]

context hepatocellular carcinoma (hcc) is a fatal disease. chronic hepatitis b virus (hbv) and/or hepatitis c virus (hcv) infection is the major cause of hcc. high viral replication rate and related hepatic/systematic inflammation are the major risk factors in hcc recurrence after hepatectomy or liver transplantation. evidence acquisition some of the carcinogenesis-related hbv mutations are als...

2016
Zongguo Yang Liping Zhuang Yunfei Lu Qingnian Xu Bozong Tang Xiaorong Chen

Basal core promoter (BCP) A1762T/G1764A dual mutations in hepatocarcinogenesis remain controversial. Published studies up to June 1, 2015 investigating the frequency of A1762T/G1764A dual mutations from chronic hepatitis B virus (HBV) infection, including hepatocellular carcinoma (HCC), were systematically identified. A total of 10,240 patients with chronic HBV infection, including 3729 HCC cas...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید