نتایج جستجو برای: hbeag
تعداد نتایج: 2019 فیلتر نتایج به سال:
The aim of this study was to assess the effect of 48-week entecavir therapy on serum and intrahepatic hepatitis B virus, covalently closed circular DNA (HBV cccDNA) levels in hepatitis B e antigen (HBeAg)-positive patients. A total of 120 patients with HBeAg-positive chronic hepatitis were treated with entecavir for 48 weeks. Serum HBV markers, total HBV DNA, and HBV cccDNA levels were measured...
چکید ه سابقه و هدف جهش در نوکلئوتید 1896 از G به A در ناحیه پرهکور ژن C ، بر روی تولید HBeAg مؤثر است. هدف از این مطالعه، تعیین شیوع جهشهای پرهکور ژن C در داوطلبان اهدای خون آلوده به HBV بود. مواد و روشها در یک مطالعه مقطعی، نمونه خون 200 اهداکننده خون که از نظر HBsAg مثبت بودند، مورد مطالعه قرار گرفتند. بر روی این نمونهها آزمایشهای HBeAg و HBeAb به روش الایزا انجام شد. HBV-DNA ...
This paper presents a summary of the evidence review group (ERG) report into the clinical and cost-effectiveness of entecavir for the treatment of chronic hepatitis B (CHB) in adults based upon a review of the manufacturer's submission to the National Institute for Health and Clinical Excellence (NICE) as part of the single technology appraisal (STA) process. The submission's evidence came from...
زمینه و اهداف: عفونت ویروس هپاتیت B هنوز یکی از مشکلات بزرگ تهدیدکننده سلامت در بیش از دو میلیارد نفر از مردم دنیا است. تعداد قابلتوجهی از جمعیت جهانی به عنوان حاملین مزمن این ویروس کشنده از ابتلای به آن رنج میبرند. متأسفانه اکثر این حاملین در جنوب شرقی آسیا زندگی میکنند. حاملین این ویروس در ایران حدود 3% میباشند. حتی با وجود منفی بودن HBsAg حضور ویروس با استفاده از روش های مولکولی در سرم ت...
Previous studies have shown that hepatitis B core antibody (anti-HBc) levels vary during different phases of disease in treatment-naïve chronic hepatitis B (CHB) patients and can be used as a predictor of both interferon-α and nucleoside analogue therapy response. However, there is no information on the association between the quantitative serum anti-HBc (qAnti-HBc) level and liver inflammation...
objective: a recent field of research in epigenetics is dna methylation which involves the cpg island in the genome that subsequently controls transcription and translation of targeted genes. in the hepatitis b virus (hbv) genome, there are three cpg islands which tend to be methylated. the aim of the current study is to determine the methylation pattern of the hbv x gene in chronically infecte...
In the United Kingdom, the National Screening Programme for identification of hepatitits B virus (HBV) infection in pregnant women uses HBV e antigen (HBeAg) and antibody to HBeAg (anti-HBe) as markers of infectivity to determine use of immunoglobulin for hepatitis B. Serum samples from 114 HBV-infected women were analyzed. Viral loads correlated with HBeAg/anti-HBe status and viral genotypes. ...
BACKGROUND Estimating the grades of liver inflammation is critical in the determination of antiviral therapy in patients chronically infected with hepatitis B virus (HBV). The aim of this study was to investigate the correlation of serum levels of hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) with the liver inflammation grades in treatment-naïve patients with chronic HBV...
To understand the mechanisms underlying the discordance between normal serum alanine aminotransferase (ALT) levels and significant alterations in liver histology of chronic hepatitis B virus (HBV) infection with persistent normal ALT (PNALT) or minimally elevated ALT. A total of 300 treatment-naive chronic HBV-infected patients with PNALT (ALT ≤ upper limit of normal [ULN, 40 U/ml]) or minimall...
Lamivudine has been shown to be effective in patients with hepatitis B e antigen (HBeAg)-positive chronic hepatitis B, but its long-term efficacy and the rate of resistant mutations in patients with HBeAg-negative chronic hepatitis B is less clear. Twenty-nine patients with HBeAg-negative chronic hepatitis B, who have received lamivudine for at least 1 year were studied to determine the antivir...
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