OBJECTIVE Aripiprazole, a dopamine system stabilizer, shows efficacy against both negative symptoms and positive symptoms in patients with schizophrenia. The aim of this study was to investigate the effects of aripiprazole and haloperidol on c-FOS expression in rat brain. METHODS Aripiprazole (1, 10 and 30 mg/kg, i.p.) and haloperidol (0.1 and 1 mg/kg, i.p.) were administered to adult Male Sp...

Dopamine D(2) receptors (D(2)R) are the primary target of antipsychotic drugs and have been shown to regulate Akt/glycogen synthase kinase-3β (GSK-3β) signaling through scaffolding protein β-arrestin 2. Amisulpride, an atypical antipsychotic drug, and haloperidol, a typical antipsychotic drug, are both potent D(2)R antagonists, but their therapeutic effects differ. In the present study, we comp...

Delirium is commonly described in critically ill patients as 1 factor contributing to increased length of intensive care unit and hospital stay, secondary complications, and increased mortality. Initial screening tools for delirium in hospitalized patients are generally easy to use; however, many centers have struggled with implementing these tools in a consistent and systematic manner. Haloper...

BACKGROUND Antipsychotic drugs are used in the routine treatment of adults with intellectual disabilities (ID) and challenging behaviour in the UK despite limited evidence of their effectiveness. There is no evidence on their cost-effectiveness. METHODS The relative cost-effectiveness of risperidone, haloperidol and placebo in treating individuals with an ID and challenging behaviour was comp...

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The effect of 1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline psychopharmacological activity on the duration sleep, which was induced with sodium etaminal, catalepsy, help haloperidol, an anti-anxiety, antidepressant activity, studied. and obtained necessary conclusions.

Patients with first-episode schizophrenia appear to respond to lower doses of neuroleptics, and to be more sensitive to developing extrapyramidal side-effects. The authors therefore compared in such patients the efficacy and extrapyramidal tolerability of comparatively low dosages of the atypical neuroleptic risperidone and of the conventional neuroleptic haloperidol. Risperidone was hypothesiz...

Immunohistochemical staining with non-specific IgG reliably labels a subset of neurons in both rat and human brain, overlapping the distribution of cortico-limbic D2 receptors (D2R). We used haloperidol to up-regulate rat D2R to observe any associated changes in IgG immunostaining. Rats were treated with haloperidol or vehicle for 30 d. Some rats were assessed for D2R up-regulation with apomorp...

Drug and alcohol dependence are associated with enhanced attention for drug-related stimuli. This cognitive processing bias has been suggested to be related to craving and to represent one of the core mechanisms of addition. The present study tests the hypothesis that enhanced attention for heroin cues is mediated by the dopaminergic system using haloperidol as dopamine antagonist. In a double ...

OBJECTIVE The brainstem-derived neuropeptide S (NPS) has a multidirectional regulatory activity, especially as a potent anxiolytic factor. Accumulating data suggests that neuroleptics affect peptidergic signalling in various brain structures. However, there is no information regarding the influence of haloperidol on NPS and NPS receptor (NPSR) expression. METHODS We assessed NPS and NPSR mRNA...