Intracranial hypertension is a common final pathway in many acute neurological conditions. However, the cerebral haemodynamic response to acute intracranial hypertension is poorly understood. We assessed cerebral haemodynamics (arterial blood pressure, intracranial pressure, laser Doppler flowmetry, basilar artery Doppler flow velocity, and vascular wall tension) in 27 basilar artery-dependent ...

OBJECTIVES The fate of the aortic dimensions in patients with a bicuspid aortic valve (BAV) after aortic valve replacement (AVR) is unclear. We investigated the evolution of aortic root and ascending aorta dimensions in patients with a BAV after AVR. To neutralize the effect of pathological transvalvular haemodynamics on aortic dimensions, we evaluated our hypotheses in patients with normal tra...

Abstract Introduction The long saphenous vein (LSV) is frequently used in cardiac surgery; however, its use complicated by late stenosis or occlusion due to the development of intimal hyperplasia (IH). TGF-β has been implicated process IH however impact acute haemodynamic changes on activation endothelial-to mesenchymal transition (EndMT) not assessed and it's focus this study. Purpose To asses...

Many techniques have been devised to measure the haemodynamics of the human and animal eye. In this perspective these are outlined and their use in ophthalmic investigation summarised. Some have exploited the ability of an observer to directly visualise the retinal vasculature by optical means, others have been designed to study the haemodynamics ofthe invisible parts of the eye such as the cho...

BACKGROUND It is generally accepted that peritoneal dialysis (PD) affects systemic haemodynamics less than haemodialysis, but little is known about changes in haemodynamics during PD. It is unknown if increasing PD volume causes changes in cardiovascular haemodynamics possibly increasing the demand on the heart even during normal daily activities. METHODS Fifteen stable PD patients were inclu...