Nucleosomal incorporation of specialized histone variants is an important mechanism to generate different functional chromatin states. Here, we describe the identification and characterization of two novel primate-specific histone H3 variants, H3.X and H3.Y. Their messenger RNAs are found in certain human cell lines, in addition to several normal and malignant human tissues. In keeping with the...

Metastatic breast cancer is one of the most common metastatic tumors. Although studies have validated the role of β-inducible gene-h3 (βig-h3) in human biology and disease, the detailed mechanisms mediated by βig-h3 in breast carcinoma metastasis remain unclear. Thus, the present study investigated the role and potential mechanism of βig-h3 during breast carcinoma cell metastasis. The results i...

Importance Alternative methods for hospital occupancy forecasting, essential information in crisis planning, are necessary a novel pandemic when traditional data sources such as disease testing limited. Objective To determine whether mandatory daily employee symptom attestation can be used syndromic surveillance to estimate COVID-19 hospitalizations the communities where emplo...

Importance Cervical cancer is highly preventable but remains a common and deadly in areas without screening programs. The creation of diagnostic system to digitize Papanicolaou test samples analyze them using cloud-based deep learning (DLS) may provide needed cervical resource-limited areas. Objective To determine whether artificial intelligence–supported digital microscopy di...

AbstractBackground The aim of the study was to analyze clinical characteristics and outcomes patients with de novo secondary adenocarcinoma arising in operatively transposed colon not exposed fecal stream. Methods Two investigators collected reviewed papers from June 1938 2019, reporting colon, contact Results Overall, we identified 98 a colonic autograft, po...

AbstractBackground The rate of tuberculosis treatment success has been relatively low due to high medication drop out which causes drug resistance and failure. Health counseling is a need for patients with help them understand accept their condition eventually increase adherence. Aim This systematic review aimed examine the effectiveness health on adherence regular pu...

SummaryBackground The optimal type of ventilation in operating theatres for joint arthroplasty has been debated decades. Recently, the World Health Organization changed its recommendations based on articles that have since criticized. economic and environmental impact is also currently an important research topic but not well investigated. Aim To compare how large, hi...

AbstractBackground Female genital mutilation (FGM) can leave a lasting mark on the lives and minds of those affected. Aim To assess consequences FGM women's sexual function in women who have undergone compared to not FGM. Methods A systematic review meta-analysis were conducted from 3 databases; inclusion exclusion criterions determined. Studies included adul...

Background Acute hamstring re-injuries are common and hard to predict. The aim of this study was investigate the association between clinical imaging findings occurrence re-injuries. Methods We obtained baseline data (clinical MRI findings) athletes who sustained an acute injury within 5 days initial injury. also collected standardised tests 7 after return play (RTP). number r...

In many types of cancer, the expression of the immunoregulatory protein B7-H3 has been associated with poor prognosis. Previously, we observed a link between B7-H3 and tumor cell migration and invasion, and in present study, we have investigated the role of B7-H3 in chemoresistance in breast cancer. We observed that silencing of B7-H3, via stable short hairpin RNA or transient short interfering...