This study compares the gonadosomatic index (GSI), oocyte growth (OG), gonadal histology, and plasma level concentrations of sex hormones (estradiol-17β (E2) and vitellogenin (V)) of twice-spawning (T-SP) and once-spawning (O-SP) females of rainbow trout throughout the additional and the normal reproductive cycle, respectively. In T-SP, the GSI values rapidly increase from May to November, in c...

BACKGROUND The Notch inhibitors, γ-secretase inhibitors (GSIs), are promising candidates for molecular targeted therapy against leukemia. However, they show only limited effectiveness. We thought that the efficacy of GSIs might be improved by their combination with Hedgehog inhibitors and Wnt inhibitors because these signaling pathways are also important for the growth of leukemia cells. MATE...

Estimating seasonal variations in demand is a challenging task faced by many organisations. There may be many stock-keeping units (SKUs) to forecast, but often data histories are short, with very few complete seasonal cycles. It has been suggested in the literature that group seasonal indices (GSI) methods should be used to take advantage of information on similar SKUs. This paper addresses two...

Security in computational Grids is mainly based on Grid Security Infrastructure (GSI) for authentication and Virtual Organization Membership Service for authorization. Although these mechanisms provide the required level of security, they lack in performance due to their dependence on public key cryptography. In our proposed security architecture we use a Kerberos-based approach (symmetric cryp...

ERBB2/neu and Notch signaling are known to be deregulated in many human cancers. However, pathway cross-talk and dependencies are not well understood. In this study, we use an ERBB2-transgenic mouse model of breast cancer (neuT) to show that Notch signaling plays a critical role in tumor maintenance. Inhibition of the Notch pathway with a gamma-secretase inhibitor (GSI) decreased both the Notch...

Penelitian mengenai biologi reproduksi ikan sembilang (Plotosus canius) di Perairan Kota Tanjungpinang Provinsi Kepulauan Riau. Tujuan penelitian ini adalah untuk mengetahui nisbah kelamin, hubungan panjang dan berat, Gonadosometik Index (GSI), fekunditas diameter telur (P.canius) Tanjungpinang. menggunakan metode survei, penentuan titik stasiun dilakukan dengan purposive samplingberdasarkan da...

Targeting glioblastoma stem cells with γ-secretase inhibitors (GSIs) disrupts the Notch pathway and has shown some benefit in both pre-clinical models and in patients during phase I/II clinical trials. However, it is largely unknown why some glioblastoma (GBM) does not respond to GSI treatment. In this issue of the JCI, Xie et al. determined that GSI-resistant brain tumor-initiating cells (BTIC...

Purpose: To determine whether uveal melanoma, the most common primary intraocular malignancy in adults, requires Notch activity for growth and metastasis. Experimental Design: Expression of Notch pathway members was characterized in primary tumor samples and in cell lines, along with the effects of Notch inhibition or activation on tumor growth and invasion. Results: Notch receptors, ligands, a...

Background: Gonadotropin releasing hormone conjugate (GnRH-BSA) raises antibodies against biologically active gonadotropin releasing hormone (GnRH) which affects body weight, gonadosomatic indices (GSI) and sperm quality in male mice. Objective: The objective of this experimental investigation is to develop an effective and reliable hormonal immunocontraceptive vaccine to suppress spermatogenes...

Database replication protocols have been usually designed in order to support a single isolation level. This paper proposes a middleware replication protocol able to manage three different isolation levels over multi-version DBMSs that provides SI level: GSI, SI, and serializable. This ensures a better support for applications that demand different isolation levels for their transactions. Addit...