INTRODUCTION We assessed the correlation between the apparent diffusion coefficient (ADC) and pathological Gleason score (GS) of prostate cancer patients. METHODS A total of 125 patients who underwent multiparametric magnetic resonance imaging before radical prostatectomy for prostate cancer were included in this study. ADC values were compared with different GS. We used receiver operating ch...

(R)-6-[(3-{[4-(5-{[2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}pent-1-yn-1-yl)phenyl] carbamoyl}phenyl)sulphonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide trifluoroacetic acid (GS-5759) is a bifunctional ligand composed of a quinolinone-containing pharmacophore [β2-adrenoceptor agonist orthostere (β2A)] found in several β2-adrenoceptor agonists, including...

with equality if and only if f and g are proportional. For p <0, we assume that f(x), g (x) >0. An (almost) improvement of Minkowski’s inequality, for p Î R\{0}, is obtained in the following Theorem: Theorem 1.2 Let f(x), g(x) ≥ 0 and p >0, or f(x), g(x) >0 and p <0. Let s, t Î R\{0}, and s ≠ t. Then (i) Let p, s, t Î R be different, such that s, t >1 and (s t)/(p t) >1. Then ∫ (f (x)+g(x))pdx ...

The combination of ombitasvir (an NS5A inhibitor), paritaprevir (an NS3/4A inhibitor) coadministered with ritonavir (r), and dasabuvir (an NS5B nonnucleoside polymerase inhibitor), referred to as the 3D regimen, and the combination of ombitasvir-paritaprevir-r, referred to as the 2D regimen, have demonstrated high efficacy with and without ribavirin in hepatitis C virus (HCV)-infected subjects....

The Bacillus subtilis GlnR repressor controls gene expression in response to nitrogen availability. Because all GlnR-regulated genes are expressed constitutively in mutants lacking glutamine synthetase (GS), GS is required for repression by GlnR. Feedback-inhibited GS (FBI-GS) was shown to activate GlnR DNA binding with an in vitro electophoretic mobility shift assay (EMSA). The activation of G...

introduction: in the current study, we compared the h-indices of web of science (wos), scopus, and gs of the iranian nuclear medicine scientists methods: full time members of two major nuclear medicine research centers of iran with more than 5 year of experience (nuclear medicine research center of mashhad university of medical sciences, and research institute for nuclear medicine of tehran uni...

introduction: in the current study, we compared the h-indices of web of science (wos), scopus, and gs of the iranian nuclear medicine scientists methods: full time members of two major nuclear medicine research centers of iran with more than 5 year of experience (nuclear medicine research center of mashhad university of medical sciences, and research institute for nuclear medicine of tehran uni...

The most common cause of inherited mental retardation, fragile X syndrome, results from a triplet repeat expansion in the FMR1 gene and loss of the mRNA binding protein, fragile X mental retardation protein (FMRP). In the absence of FMRP, signaling through group I metabotropic glutamate receptors (mGluRs) is enhanced. We previously proposed a mechanism whereby the audiogenic seizures exhibited ...