Levels of itraconazole and its metabolite hydroxy-itraconazole were measured by HPLC in plasma samples from guinea pigs and DBA/2 and BALB/c mice after oral or intraperitoneal treatment with itraconazole/cyclodextrin solution at 5 and 20 mg/kg daily for 7 days. The animals were randomly assigned to receive grapefruit juice or drinking water in their fluid bottles, since components of grapefruit...

OBJECTIVE To evaluate the ameliorative role of grapefruit juice on the cytogenetic and testicular damage induced by the antiarrythmic drug amiodarone in albino rats. METHODS Animals were divided into four groups. Group I was considered as control. Group II was given grapefruit juice at a dose level of 27 mL/kg body weight. Group III was orally administered amiodarone (18 mg/kg body weight) da...

A tape peeling model based on the geometry of the peel zone (PZ) is derived to predict the peeling behavior of adhesive tapes at peel angles less than or equal to 90o. The PZ model adds an angle-dependent multiplier to the ‘Kendall equation’ that takes into account the geometrical changes within the peel zone. The model is compared to experimental measurements of the peel force at different ang...

The effective substances (polyphenols, phenolic and ascorbic acids, flavonoids and dietary fibers) and antioxidative activities, using different radical-scavenging tests, were determined for Jaffa sweeties and grapefruit. The antioxidative activities comprised the contributions from polyphenols, phenolic acids, flavonoids and ascorbate components, and were well-correlated with polyphenols and f...

In order to develop a database for flavanones, the dominant flavonoid class in the genus citrus, the relevant scientific literature on flavonoids in grapefruit, lemons, and limes was searched, abstracted, documented, standardized by taxons and units (mg/100 g) and examined for quality. Values for eight flavanones (didymin, eriocitrin, hesperidin, naringin, narirutin, neoeriocitrin, neohesperidi...

Chemical control of the citrus nematode, Tylenchulus semipenetrans Cobb, has consistently increased yield of grapefruit on sour orange rootstock in Texas. In this study, data from chemical control tests conducted from 1973 to 1980 were analyzed to determine the relationship between nematode counts and grapefruit yield and fruit size. The correlation between yield and nematode counts was negativ...

This study was conducted to investigate the effects of feeding fresh Gliricidia sepium leaves as supplement to basal diet of dried cassava peel on the haematological parameters of West African Dwarf sheep and goats in a completely randomized design experiment. Twelve each of WAD sheep and goat were randomly divided into three groups of four animals per group for both sheep and goats. The three ...

The colouring agents, as food additive, is believed to be necessary for producers. Because of the toxic effects of nitrite, to replace the use of nitrite mostly natural additives. Tomato industries yield a high amount of by-products mainly tomato peel and seeds. Since tomato peel is rich in lycopene, it can be added directly in 0%, 3% and 6% (w/w) in meat mixture used in beef sausage manufactur...

Roughing disorder (RD) is a significant quality barrier in citrus fruit, prevalent on easy-peeling mandarins. As RD is not yet well-understood, this study aimed to examine the changes and synergic molecular processes involved in peel RD. Peel with RD was induced by severely defruiting Satsuma mandarin trees. Morphology observations, RNA-sequencing, and targeted and untargeted metabolic analyses...