نتایج جستجو برای: granulopoiesis
تعداد نتایج: 691 فیلتر نتایج به سال:
C57BL x DBA/2 F5mice bred in our laboratory from stock purchased from The Jackson Laboratory, Ban Harbor, Maine, were used in all experiments. Animals were between 8 and 15 weeks of age. Cyclophosphamide (100 mg) with sodium chloride (45 mg) (Mead Johnson Laboratories, Evansville, Ind.) was dissolved in 5 ml preservative-free sterile water and admin istered (200 mg/kg) i.p. Control mice were gi...
We have previously shown that basic fibroblast growth factor (bFGF) is mitogenic for human bone marrow stromal cells and enhances myelopoiesis in human long-term bone marrow culture. In the present study, we examined the mechanism by which bFGF enhances granulopoiesis. We observed that bFGF significantly abrogated the inhibitory effect of transforming growth factor-j3l (TGF-PI) on granulocyte-m...
I N 1955, when studies were initiated in our laboratory to determine the suitability of radioactive diisopropylfluorophosphate ( DFP32) as a label for granulocytes, information concerning the rate of production and movement of these cells was very meager as compared with knowledge of erythrokinetics. Since that time, with the development and application of the DFP32 cytoplasmic granulocyte labe...
Bone marrow cellularity is mildly increased as a result of a moderate degree of erythroid hyperplasia. Erythropoiesis is micronormoblastic with erythroblasts being smaller than normal with scanty or ragged cytoplasm or with cytoplasmic vacuolation (Fig. 8.1). There is a minor degree of dyserythropoiesis. An iron stain shows siderotic granules to be severely reduced or absent and there is a comp...
The effect of endotoxin on the tibial in vitro colony-forming cell (CFC) and the differentiated granulocyte compartment was evaluated. The injection of 5 g of Salmonella typhosa endotoxin into CF, mice leads to elevated serum colony-stimulating factor (CSF) levels along with a transient granulocytopenia followed by the release of granulocytes from the marrow. The present study demonstrates that...
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