Scaling up is one of the difficulties faced by production process pharmaceutical industry. We must manufacture in higher quantities than a laboratory size with set requirements as we scale up. Understanding crucial variables that affect final product's specifications will aid choosing appropriate upgrade settings. Fluidized-bed granulation most frequently used techniques to increase The complex...

Identification of recurrent cholesteatoma and differentiation from postoperative granulation tissue is important in a patient who has undergone mastoidectomy for cholesteatoma. We describe the diffusion-weighted imaging findings and apparent diffusion coefficient values in a case of recurrent cholesteatoma. This case suggests possible differentiation of cholesteatoma from granulation tissue on ...

OBJECTIVE To study the pathogenesis of the pain of discography and the discogenic low back pain. METHODS 19 specimens of lumbar intervertebral discs from 17 patients with discogenic low back pain during posterior lumbar interbody fusion, and 12 physiologically aging discs and 10 normal control discs were collected to investigate the morphologic features and innervation containing neuropeptide...

Researches in granular modeling produced a variety of mathematical models, such as intervals, (higher-order) fuzzy sets, rough sets, and shadowed sets, which are all suitable to characterize the socalled information granules. Modeling of the input data uncertainty is recognized as a crucial aspect in information granulation. Moreover, the uncertainty is a well-studied concept in many mathematic...

Breakthrough energy savings were recently projected by a spray-dryer free dairy powder manufacturing process based on superconcentration and granulation. The extent of the recirculation rate for granulation, determines performance. In this study, evolution physical properties during granulation was investigated model system (skim milk microfiltrate) using rheological shear-cell techniques. Resu...

OBJECTIVE Negative pressure wound therapy (NPWT) is commonly used in the continuous mode. Intermittent pressure therapy (IPT) results in faster wound healing, but it often causes pain. Variable pressure therapy (VPT) has therefore been introduced to provide a smooth transition between 2 different pressure environments, thereby maintaining the negative pressure environment throughout the therapy...